The fundamental goal of the Pediatric Center of Excellence in Nephrology at Cincinnati Children's Hospital Medical Center (CCHMC PCEN) is to support basic, translational, and clinical research, focused on three identified critical pediatric kidney diseases that have major unmet needs. Major components of this goal include to attract outstanding scientific expertise to the study of these focus areas in a multidisciplinary manner, to provide high-resource Cores to support research that utilizes technologies in a timely and efficient manner, and to support novel exploratory pilot projects from promising individuals that represent the future generations of leaders in the focus areas. The primary goal of the Administrative Core is to ensure that the CCHMC PCEN Center functions as a well-coordinated and highly integrated interdisciplinary research platform that synergizes with each Center member's investigation into the three identified critical pediatric kidney disease focus areas. This will be accomplished by organizing interdisciplinary scientific exchanges, providing support in key administrative and secretarial areas, providing web-based communications and information technology, and by administering the Pilot and Feasibility Program and the Enrichment Program. Thus, the Administrative Core will oversee all functions of the CCHMC PCEN Center, including membership, core services, enrichment program, pilot and feasibility program, monitoring scientific output, financial supervision, and budget management The Specific Aims of the Administrative Core are;
Aim 1. To provide leadership and set the agenda for the research goals of the Center Aim 2. To provide administrative, clerical, finance and budget management support to Center members Aim 3. To provide biostatistical, bioinformatics, and information technology support to Center members Aim 4. To organize an Internal Advisory Board and an External Advisory Board Aim 5. To organize and implement the Pilot/Feasibility and Enrichment Programs

Public Health Relevance

Pediatric kidney diseases due to acute kidney injury, focal segmental glomerulosclerosis, and lupus nephritis contribute to an enormous major impact on the U.S. public health and a major financial burden. The Administrative Core of this Center of Excellence in Nephrology will bring together experts from multiple facets of science to focus their energies on these three disease states to change their dismal outcomes.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
United States
Zip Code
Nehus, Edward; Kaddourah, Ahmad; Bennett, Michael et al. (2017) Subclinical Kidney Injury in Children Receiving Nonsteroidal Anti-Inflammatory Drugs After Cardiac Surgery. J Pediatr 189:175-180
Varnell Jr, Charles D; Goldstein, Stuart L; Devarajan, Prasad et al. (2017) Impact of Near Real-Time Urine Neutrophil Gelatinase-Associated Lipocalin Assessment on Clinical Practice. Kidney Int Rep 2:1243-1249
Bennett, Michael R; Pleasant, LaTawnya; Haffner, Christopher et al. (2017) A Novel Biomarker Panel to Identify Steroid Resistance in Childhood Idiopathic Nephrotic Syndrome. Biomark Insights 12:1177271917695832
Turnier, Jessica L; Fall, Ndate; Thornton, Sherry et al. (2017) Urine S100 proteins as potential biomarkers of lupus nephritis activity. Arthritis Res Ther 19:242
Garimella, Pranav S; Jaber, Bertrand L; Tighiouart, Hocine et al. (2017) Association of Preoperative Urinary Uromodulin with AKI after Cardiac Surgery. Clin J Am Soc Nephrol 12:10-18
Garimella, Pranav S; Bartz, Traci M; Ix, Joachim H et al. (2017) Urinary Uromodulin and Risk of Urinary Tract Infections: The Cardiovascular Health Study. Am J Kidney Dis 69:744-751
Gulati, G; Bennett, M R; Abulaban, K et al. (2017) Prospective validation of a novel renal activity index of lupus nephritis. Lupus 26:927-936
Devarajan, Prasad; Basu, Rajit K (2017) Sepsis-associated acute kidney injury - is it possible to move the needle against this syndrome? J Pediatr (Rio J) 93:1-3
Kamal, Fadia A; Travers, Joshua G; Schafer, Allison E et al. (2017) G Protein-Coupled Receptor-G-Protein ??-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure. J Am Soc Nephrol 28:197-208
Pleasant, LaTawnya; Ma, Qing; Devarajan, Mahima et al. (2017) Increased susceptibility to structural acute kidney injury in a mouse model of presymptomatic cardiomyopathy. Am J Physiol Renal Physiol 313:F699-F705

Showing the most recent 10 out of 97 publications