The overall objective of the Controlled Exposure Facility core is to provide capabilities for the study of humanand animal toxicological responses to inhalation exposures of combustion-generated particles and gases.This core will primarily provide technical support, facilities, management and coordination of controlledexposure experiments for the toxicology and human clinical studies, and will also provide technical advice tothe epidemiology project on characterization of atmospheric aerosols, exposure assessment of airborneparticles and gases, and source/receptor relationships of ambient air pollutants. . The combustion exhaustexposures in support of the toxicology and human clinical studies will take place in a recently built and wellcharacterizedexposure facility in the Northlake Laboratory of the University of Washington. This exposuregeneration and characterization activity will be achieved via the following specific aims: 1) Generate relevantcombustion exhaust exposure atmospheres; 2: Characterize particles and gases generated during eachexposure; 3) Modify exposure atmospheres to enhance understanding of the toxicity of diesel exhaust.These modifications will provide experimental conditions that permit experimental evaluation of toxicity tobiological systems.
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