The overall objective of this DISCOVER Center is to investigate the mechanisms by which traffic-related air pollution causes myocardial infarction and other cardiovascular diseases, by integrating a diverse set of research approaches. Air pollution exposures have been consistently associated with cardiovascular disease. A growing literature indicates that the major source of variation in air pollution's cardiovascular health effects is from exposure to traffic. Diesel exhaust is an excellent model exposure. The closely linked suite of activities in this DISCOVER Center will attempt to understand the mechanisms (molecular mechanisms that cause vasoconstriction and acceleration of atherosclerosis) underlying exposure-related effects, and use environmental exposures to understand basic mechanisms regarding vascular biology. The studies will exploit exposure contrasts in experimental and epidemiological studies through advanced exposure assessment methods, and genetic diversity in both human and animal studies, to advance our aims. The application brings together a cohesive group of five projects (two patient-oriented and three basic mechanistic studies) and three cores, Administrative, Exposure Science, and Biostatistics and Bioinformatics. Project 1 investigates the mechanism underlying vascular response in humans following controlled exposure to diesel exhaust;Project 2 studies genetic modifiers on the effect of traffic-related air pollution on vascular response and atherosclerosis in a population-based human observational study. Project 3 investigates the role of systemic inflammation in the vascular response to diesel exhaust. Project 4 investigates the impact of diesel exhaust exposure on myocardial injury and apoptosis. Project 5 investigates reactive oxygen species and oxidative stress in the vascular response to diesel exhaust. Through this research, the investigators will develop knowledge that can be used to develop preventive and therapeutic strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Specialized Center (P50)
Project #
5P50ES015915-05
Application #
8278537
Study Section
Special Emphasis Panel (ZES1-JAB-C (DI))
Program Officer
Mcallister, Kimberly A
Project Start
2008-06-01
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
5
Fiscal Year
2012
Total Cost
$2,402,615
Indirect Cost
$873,368
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hom, Elizabeth K; Duprez, Daniel A; Jacobs Jr, David R et al. (2016) Comparing Arterial Function Parameters for the Prediction of Coronary Heart Disease Events: The Multi-Ethnic Study of Atherosclerosis (MESA). Am J Epidemiol 184:894-901
Sack, Cora S; Jansen, Karen L; Cosselman, Kristen E et al. (2016) Pretreatment with Antioxidants Augments the Acute Arterial Vasoconstriction Caused by Diesel Exhaust Inhalation. Am J Respir Crit Care Med 193:1000-7
Bergen, Silas; Sheppard, Lianne; Kaufman, Joel D et al. (2016) Multipollutant measurement error in air pollution epidemiology studies arising from predicting exposures with penalized regression splines. J R Stat Soc Ser C Appl Stat 65:731-753
Larson, Nicholas B; Bell, Elizabeth J; Decker, Paul A et al. (2016) ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 251:422-9
Kim, Sun-Young; Sheppard, Lianne; Bergen, Silas et al. (2016) Prediction of fine particulate matter chemical components with a spatio-temporal model for the Multi-Ethnic Study of Atherosclerosis cohort. J Expo Sci Environ Epidemiol 26:520-8
Sack, Cora S; Kaufman, Joel D (2016) Air Pollution Levels and Children's Lung Health. How Low Do We Need to Go? Am J Respir Crit Care Med 193:819-20
Chi, Gloria C; Hajat, Anjum; Bird, Chloe E et al. (2016) Individual and Neighborhood Socioeconomic Status and the Association between Air Pollution and Cardiovascular Disease. Environ Health Perspect 124:1840-1847
Spalt, Elizabeth W; Curl, Cynthia L; Allen, Ryan W et al. (2016) Time-location patterns of a diverse population of older adults: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). J Expo Sci Environ Epidemiol 26:349-55
Spalt, Elizabeth W; Curl, Cynthia L; Allen, Ryan W et al. (2016) Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). J Expo Sci Environ Epidemiol 26:341-8
Weuve, Jennifer; Kaufman, Joel D; Szpiro, Adam A et al. (2016) Exposure to Traffic-Related Air Pollution in Relation to Progression in Physical Disability among Older Adults. Environ Health Perspect 124:1000-8

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