Biostatistics and bioinformatics support of environmental health research requires increasingly skilled and specialized methods. High quality data and analysis contributes to the overall potential for high quality, statistically sound research. The Biostatistics and Bioinformatics Core will be a powerful unifying force in the DISCOVER Center by engaging in interdisciplinary interactions, supporting multiple projects and databases, and providing biostatistics, bioinformatics, and database management support. Biostatistics support will be in the areas of epidemiology, spatial modeling, and experimental design/analysis. The bioinformatics needs of the genetic epidemiology, functional genomics, and proteomics portions of the studies will be met either directly by this Core or by leveraging resources of the Bioinformatics Core of the Center for Ecogenetics and Environmental Health (CEEH). The Core services and activities are: 1. Statistical consultation for all projects and investigators. This includes consultation on study design, sample size calculations, data collection and analysis, and interpretation of study results; 2. Data management for selected the DISCOVER Center projects; 3. Data compilation from existing databases; 4. Bioinformatics support and liaison to CEEH; 5. Communicate and disseminate Center findings;and 6. Identification of topics for statistical methods development and innovative approaches to statistical analyses. This Core will serve all projects.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-JAB-C)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
United States
Zip Code
Hom, Elizabeth K; Duprez, Daniel A; Jacobs Jr, David R et al. (2016) Comparing Arterial Function Parameters for the Prediction of Coronary Heart Disease Events: The Multi-Ethnic Study of Atherosclerosis (MESA). Am J Epidemiol 184:894-901
Sack, Cora S; Jansen, Karen L; Cosselman, Kristen E et al. (2016) Pretreatment with Antioxidants Augments the Acute Arterial Vasoconstriction Caused by Diesel Exhaust Inhalation. Am J Respir Crit Care Med 193:1000-7
Bergen, Silas; Sheppard, Lianne; Kaufman, Joel D et al. (2016) Multipollutant measurement error in air pollution epidemiology studies arising from predicting exposures with penalized regression splines. J R Stat Soc Ser C Appl Stat 65:731-753
Larson, Nicholas B; Bell, Elizabeth J; Decker, Paul A et al. (2016) ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 251:422-9
Kim, Sun-Young; Sheppard, Lianne; Bergen, Silas et al. (2016) Prediction of fine particulate matter chemical components with a spatio-temporal model for the Multi-Ethnic Study of Atherosclerosis cohort. J Expo Sci Environ Epidemiol 26:520-8
Sack, Cora S; Kaufman, Joel D (2016) Air Pollution Levels and Children's Lung Health. How Low Do We Need to Go? Am J Respir Crit Care Med 193:819-20
Chi, Gloria C; Hajat, Anjum; Bird, Chloe E et al. (2016) Individual and Neighborhood Socioeconomic Status and the Association between Air Pollution and Cardiovascular Disease. Environ Health Perspect 124:1840-1847
Spalt, Elizabeth W; Curl, Cynthia L; Allen, Ryan W et al. (2016) Time-location patterns of a diverse population of older adults: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). J Expo Sci Environ Epidemiol 26:349-55
Spalt, Elizabeth W; Curl, Cynthia L; Allen, Ryan W et al. (2016) Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). J Expo Sci Environ Epidemiol 26:341-8
Weuve, Jennifer; Kaufman, Joel D; Szpiro, Adam A et al. (2016) Exposure to Traffic-Related Air Pollution in Relation to Progression in Physical Disability among Older Adults. Environ Health Perspect 124:1000-8

Showing the most recent 10 out of 71 publications