The Sorger group will continue its quantitative analysis of signal transduction in mammalian cells with particular focus on pathways downstream of ErbB, IGF1 and cMet growth factor receptors and TNF, TRAIL and Fas death receptors. Measurement in single cells and cell populations will be accompanied by mathematical modeling using a variety of methods ranging from purely statistical to physico-chemical. The Gunawardena group will work closely with members of the Sorger group, and with other CDP labs, in developing new methods to model and analyze biological networks. Development and application of the Little b programming environment will be of particular importance. With respect to Core activities the focus will be on efficient reagent acquisition, generation and distribution in the Molecular Genetics core and web-based information technologies in the Informatics Core. The informatics core will develop methods for integrating experiments and models, while also providing programming support for central activities resources as CDPWiki, the CDP web site and conference registration. The Outreach core is responsible for overall management of non-scientific programs in CDP across two campuses, with particular focus on annual meetings, retreats, student and educational activities and recruiting for the sabbatical program. Financial support and scientific mentors for the New England Science Symposium will also be provided. HMS-based administration will support the cores in their programmatic functions. The outreach core will work closely with the Scientific Coordination team, which comprises highly experienced postdoctoral fellows, as well as with the PI, in preparing annual reports, updating the web site and guiding collaborative projects among CDP labs.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-CBCB-4)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts Institute of Technology
United States
Zip Code
Jaqaman, Khuloud; Galbraith, James A; Davidson, Michael W et al. (2016) Changes in single-molecule integrin dynamics linked to local cellular behavior. Mol Biol Cell 27:1561-9
Qian, Wen-Jian; Park, Jung-Eun; Grant, Robert et al. (2015) Neighbor-directed histidine N (Ï„)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles. Biopolymers 104:663-73
Hsu, Albert T; Barrett, Christopher D; DeBusk, George M et al. (2015) Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Shock 44:128-36
Ramírez-Gordillo, Daniel; Powers, TuShun R; van Velkinburgh, Jennifer C et al. (2015) RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance. BMC Res Notes 8:691
Landry, Benjamin D; Clarke, David C; Lee, Michael J (2015) Studying Cellular Signal Transduction with OMIC Technologies. J Mol Biol 427:3416-40
Dutta, Sanjib; Ryan, Jeremy; Chen, T Scott et al. (2015) Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL. J Mol Biol 427:1241-53
Sarkar, Aniruddh; Kolitz, Sarah; Lauffenburger, Douglas A et al. (2014) Microfluidic probe for single-cell analysis in adherent tissue culture. Nat Commun 5:3421
Ebrahimkhani, Mohammad R; Neiman, Jaclyn A Shepard; Raredon, Micha Sam B et al. (2014) Bioreactor technologies to support liver function in vitro. Adv Drug Deliv Rev 69-70:132-57
Kallenberger, Stefan M; Beaudouin, Joël; Claus, Juliane et al. (2014) Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Sci Signal 7:ra23
Bryan, Andrea K; Hecht, Vivian C; Shen, Wenjiang et al. (2014) Measuring single cell mass, volume, and density with dual suspended microchannel resonators. Lab Chip 14:569-76

Showing the most recent 10 out of 220 publications