The Sorger group will continue its quantitative analysis of signal transduction in mammalian cells with particular focus on pathways downstream of ErbB, IGF1 and cMet growth factor receptors and TNF, TRAIL and Fas death receptors. Measurement in single cells and cell populations will be accompanied by mathematical modeling using a variety of methods ranging from purely statistical to physico-chemical. The Gunawardena group will work closely with members of the Sorger group, and with other CDP labs, in developing new methods to model and analyze biological networks. Development and application of the Little b programming environment will be of particular importance. With respect to Core activities the focus will be on efficient reagent acquisition, generation and distribution in the Molecular Genetics core and web-based information technologies in the Informatics Core. The informatics core will develop methods for integrating experiments and models, while also providing programming support for central activities resources as CDPWiki, the CDP web site and conference registration. The Outreach core is responsible for overall management of non-scientific programs in CDP across two campuses, with particular focus on annual meetings, retreats, student and educational activities and recruiting for the sabbatical program. Financial support and scientific mentors for the New England Science Symposium will also be provided. HMS-based administration will support the cores in their programmatic functions. The outreach core will work closely with the Scientific Coordination team, which comprises highly experienced postdoctoral fellows, as well as with the PI, in preparing annual reports, updating the web site and guiding collaborative projects among CDP labs.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM068762-10
Application #
8381021
Study Section
Special Emphasis Panel (ZGM1-CBCB-4)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
10
Fiscal Year
2012
Total Cost
$116,017
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Jaqaman, Khuloud; Galbraith, James A; Davidson, Michael W et al. (2016) Changes in single-molecule integrin dynamics linked to local cellular behavior. Mol Biol Cell 27:1561-9
Hsu, Albert T; Barrett, Christopher D; DeBusk, George M et al. (2015) Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Shock 44:128-36
Landry, Benjamin D; Clarke, David C; Lee, Michael J (2015) Studying Cellular Signal Transduction with OMIC Technologies. J Mol Biol 427:3416-40
Qian, Wen-Jian; Park, Jung-Eun; Grant, Robert et al. (2015) Neighbor-directed histidine N (?)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles. Biopolymers 104:663-73
Dutta, Sanjib; Ryan, Jeremy; Chen, T Scott et al. (2015) Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL. J Mol Biol 427:1241-53
Ramírez-Gordillo, Daniel; Powers, TuShun R; van Velkinburgh, Jennifer C et al. (2015) RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance. BMC Res Notes 8:691
Sarkar, Aniruddh; Kolitz, Sarah; Lauffenburger, Douglas A et al. (2014) Microfluidic probe for single-cell analysis in adherent tissue culture. Nat Commun 5:3421
Buck, Lorenna D; Inman, S Walker; Rusyn, Ivan et al. (2014) Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix. Biotechnol Bioeng 111:1018-27
Ebrahimkhani, Mohammad R; Neiman, Jaclyn A Shepard; Raredon, Micha Sam B et al. (2014) Bioreactor technologies to support liver function in vitro. Adv Drug Deliv Rev 69-70:132-57
Griffith, Linda G; Wells, Alan; Stolz, Donna B (2014) Engineering liver. Hepatology 60:1426-34

Showing the most recent 10 out of 220 publications