PROJECT 3 - HOST-PATHAGEN INTERACTIONS Project Leader: T. Shenk (Molbio) This project is focused on mechanisms intrinsic to the growth and spread of viral, parasitic and bacterial pathogens. Shenk will study mechanisms by which innate immunity limits the replication and spread of human cytomegalovirus, Enquist will explore how pseudorabies virus moves within neurons and spreads between neurons, Llinas will study transcriptional regulation and small molecule metabolism in malaria, Gital/Shaevitz will elucidate the mechanisms by which the peptidoglycan cell wall network of gram-negative bacteria is spatially and temporally organized, and Bassler will study quorum sensing in a variety of bacterial systems.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM071508-10
Application #
8534151
Study Section
Special Emphasis Panel (ZGM1-CBCB-4)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
10
Fiscal Year
2013
Total Cost
$234,261
Indirect Cost
$87,686
Name
Princeton University
Department
Type
DUNS #
002484665
City
Princeton
State
NJ
Country
United States
Zip Code
08544
Zhou, Jian; Troyanskaya, Olga G (2016) Probabilistic modelling of chromatin code landscape reveals functional diversity of enhancer-like chromatin states. Nat Commun 7:10528
Cobbold, Simon A; Santos, Joana M; Ochoa, Alejandro et al. (2016) Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. Sci Rep 6:19722
Cobbold, Simon A; Llinás, Manuel; Kirk, Kiaran (2016) Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum. Cell Microbiol 18:820-30
Berman, Gordon J; Bialek, William; Shaevitz, Joshua W (2016) Predictability and hierarchy in Drosophila behavior. Proc Natl Acad Sci U S A 113:11943-11948
Kamphorst, Jurre J; Nofal, Michel; Commisso, Cosimo et al. (2015) Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res 75:544-53
Bothma, Jacques P; Garcia, Hernan G; Ng, Samuel et al. (2015) Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo. Elife 4:
Purdy, John G; Shenk, Thomas; Rabinowitz, Joshua D (2015) Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Rep 10:1375-85
Fan, Jing; Teng, Xin; Liu, Ling et al. (2015) Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. ACS Chem Biol 10:510-6
Haye, Joanna E; Gammie, Alison E (2015) The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis. PLoS Genet 11:e1005719
Parsons, Lance R; Tafuri, Yolanda R; Shreve, Jacob T et al. (2015) Rapid genome assembly and comparison decode intrastrain variation in human alphaherpesviruses. MBio 6:

Showing the most recent 10 out of 429 publications