Project D: Using Diversity Outbred mice to study metabolic traits;Karen L. Svenson (Jackson) This project will use Diversity Outbred (DO) mice to identify genes involved in complex biological pathways related to metabolic syndrome using a high fat diet perturbation. Mixed genomes in experimental models have historically imposed enormous hurdles to sorting out relevant functional components of fundamental biological processes. With current technologies for high-density genotyping, genetically heterogeneous population is now a welcome resource for interrogating nuances of multiple biological systems that support and maintain life. Adding an environmental perturbation, high fat diet, will help to recapitulate a specific challenge to humans that is increasingly recognized as a significant driver of overall health. This research plan provides an opportunity to integrate with other Center projects to build a gene-environment interaction of complex metabolic processes by generating comprehensive resources to be utilized in studies of epigenetics (Project A), genotype-phenotype networks (Projects E and G), RNA processing (Project F), gene expression (Project G), and metabolites (Project H) under perturbed environmental conditions.

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
5P50GM076468-09
Application #
8691876
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
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Gatti, Daniel M; Svenson, Karen L; Shabalin, Andrey et al. (2014) Quantitative trait locus mapping methods for diversity outbred mice. G3 (Bethesda) 4:1623-33

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