Systems Biology seeks to explain the complexity of life by revealing the basic strategies used by organisms to carry out diverse, demanding tasks in an uncertain world. Many Systems Biological approaches focus on the dynamic nature of living systems, but cells, tissues, and organisms don't just vary in time, they vary in space. Patterns must be specified, shapes and sizes must be controlled, and transport of signals and cargoes from one location to another must be regulated. For the last 4-1/2 years, the Center for Complex Biological Systems at the University of California, Irvine has operated as a National Center for Systems Biology, with a focus on Spatial Dynamics, the study of spatial phenomena and spatial design principles in biology. Taking advantage of collective strength in modeling, imaging and experimental methods, teams of molecular and cellular biologists, mathematicians, computer scientists, physicists and engineers have worked together to tackle a variety of spatial problems, from the subcellular to the organ level. During the next five years, the center proposes to extend this work with new research in five theme areas: pattern formation;tissue growth control;spatial control of intracellular signaling;development of mathematical and computational tools;and developmental of optical tools for spatial dynamics and nano-imaging. In addition, the center will maintain and expand upon an array of educational and outreach activities developed during the current funding period, including graduate, undergraduate and high school training activities;a short course for professionals in Systems Biology;faculty recruiting;symposia, workshops, regional meetings, retreats, and activities aimed at promoting workforce diversity.

Public Health Relevance

Spatially dynamic processes are crucial to development, regeneration, wound healing, and gene expression. Understanding such processes will provide deep insights into diverse pathological processes ranging from birth defects, to cancer, to aging. Training and outreach in Systems Biology will help prepare the scientific workforce to tackle the complex, multi-disciplinary challenges of investigating biological spatial dynamics.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076516-08
Application #
8731903
Study Section
Special Emphasis Panel (ZGM1-CBCB-3 (SB))
Program Officer
Lyster, Peter
Project Start
2007-08-01
Project End
2017-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
8
Fiscal Year
2014
Total Cost
$2,082,438
Indirect Cost
$696,769
Name
University of California Irvine
Department
Anatomy/Cell Biology
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Lee, Mary; Chen, George T; Puttock, Eric et al. (2017) Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol 13:912
Bhattacharjee, Arunima; Datta, Rupsa; Gratton, Enrico et al. (2017) Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy. Sci Rep 7:3743
Digiacomo, L; Cardarelli, F; Pozzi, D et al. (2017) An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles. Nanoscale 9:17254-17262
Li, Chung-Jung; Hong, Tian; Tung, Ying-Tsen et al. (2017) MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord. Nat Commun 8:14685
Wan, Frederic Y M; Enciso, Germán A (2017) Optimal Proliferation and Differentiation of Chlamydia Trachomatis. Stud Appl Math 139:129-178
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Bardwell, A Jane; Lagunes, Leonila; Zebarjedi, Ronak et al. (2017) The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2. J Biol Chem 292:8750-8761
Bohórquez-Hernández, A; Gratton, Enrico; Pacheco, Jonathan et al. (2017) Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains. Biochim Biophys Acta 1862:1481-1490
Malacrida, Leonel; Jameson, David M; Gratton, Enrico (2017) A multidimensional phasor approach reveals LAURDAN photophysics in NIH-3T3 cell membranes. Sci Rep 7:9215
Liu, Kai; Marple, Gary R; Allard, Jun et al. (2017) Dynamics of a multicomponent vesicle in shear flow. Soft Matter 13:3521-3531

Showing the most recent 10 out of 375 publications