THEME A - CONTROL OF PATTERN (Arthur Lander, Theme Leader) I Understanding pattern - the regular arrangement of cells and cellular behaviors in space - is one of the oldest problems in biology. Over the past half-century, two views of pattern formation have flourished [63,64], both appealing to the actions of molecules, termed morphogens, that spread within tissues. In "boundary-organized' patterning, long-range morphogen gradients provide positional Information, giving cells their coordinates with respect to a frame of reference. In "self-organizing" patterning, morphogens act over shorter range to induce or repress expression of themselves or other morphogens, which in turn influences their own activity. Such feedback creates instabilities that lead to spontaneous division of cell groups into repeating units.
Aim A l , below, explores changing concepts in how long-range morphogens control pattern.
Aim A2 pursues the idea that patterning is often neither boundary- nor self-organized, but a combination of both.
A third aim explores how pattern control and growth control are coordinated (it is designated Aim ABS, to reflect the fact that it will be a joint effort between Theme A [pattern] and Theme B [growth control]).

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076516-08
Application #
8731905
Study Section
Special Emphasis Panel (ZGM1-CBCB-3)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
8
Fiscal Year
2014
Total Cost
$315,274
Indirect Cost
$106,184
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Kang, Dong-Ku; Ali, M Monsur; Zhang, Kaixiang et al. (2014) Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nat Commun 5:5427
Seiler, Magdalene J; Aramant, Robert B; Jones, Melissa K et al. (2014) A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression. Graefes Arch Clin Exp Ophthalmol 252:1079-92
Pate, Kira T; Stringari, Chiara; Sprowl-Tanio, Stephanie et al. (2014) Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J 33:1454-73
Annibale, Paolo; Gratton, Enrico (2014) Advanced fluorescence microscopy methods for the real-time study of transcription and chromatin dynamics. Transcription 5:
Paladino, Simona; Lebreton, St├ęphanie; Tivodar, Simona et al. (2014) Golgi sorting regulates organization and activity of GPI proteins at apical membranes. Nat Chem Biol 10:350-7
Lei, Jinzhi; Levin, Simon A; Nie, Qing (2014) Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation. Proc Natl Acad Sci U S A 111:E880-7
Conesa, Ana; Mortazavi, Ali (2014) The common ground of genomics and systems biology. BMC Syst Biol 8 Suppl 2:S1
Bonaventura, Gabriele; Barcellona, Maria Luisa; Golfetto, Ottavia et al. (2014) Laurdan monitors different lipids content in eukaryotic membrane during embryonic neural development. Cell Biochem Biophys 70:785-94
Holmes, William R (2014) An efficient, nonlinear stability analysis for detecting pattern formation in reaction diffusion systems. Bull Math Biol 76:157-83
Aland, Sebastian; Egerer, Sabine; Lowengrub, John et al. (2014) Diffuse interface models of locally inextensible vesicles in a viscous fluid. J Comput Phys 277:32-47

Showing the most recent 10 out of 176 publications