THEME A - CONTROL OF PATTERN (Arthur Lander, Theme Leader) I Understanding pattern - the regular arrangement of cells and cellular behaviors in space - is one of the oldest problems in biology. Over the past half-century, two views of pattern formation have flourished [63,64], both appealing to the actions of molecules, termed morphogens, that spread within tissues. In """"""""boundary-organized' patterning, long-range morphogen gradients provide positional Information, giving cells their coordinates with respect to a frame of reference. In """"""""self-organizing"""""""" patterning, morphogens act over shorter range to induce or repress expression of themselves or other morphogens, which in turn influences their own activity. Such feedback creates instabilities that lead to spontaneous division of cell groups into repeating units.
Aim A l , below, explores changing concepts in how long-range morphogens control pattern.
Aim A2 pursues the idea that patterning is often neither boundary- nor self-organized, but a combination of both.
A third aim explores how pattern control and growth control are coordinated (it is designated Aim ABS, to reflect the fact that it will be a joint effort between Theme A [pattern] and Theme B [growth control]).

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076516-08
Application #
8731905
Study Section
Special Emphasis Panel (ZGM1-CBCB-3)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
8
Fiscal Year
2014
Total Cost
$315,274
Indirect Cost
$106,184
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Lee, Mary; Chen, George T; Puttock, Eric et al. (2017) Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol 13:912
Bhattacharjee, Arunima; Datta, Rupsa; Gratton, Enrico et al. (2017) Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy. Sci Rep 7:3743
Digiacomo, L; Cardarelli, F; Pozzi, D et al. (2017) An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles. Nanoscale 9:17254-17262
Li, Chung-Jung; Hong, Tian; Tung, Ying-Tsen et al. (2017) MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord. Nat Commun 8:14685
Wan, Frederic Y M; Enciso, Germán A (2017) Optimal Proliferation and Differentiation of Chlamydia Trachomatis. Stud Appl Math 139:129-178
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Bardwell, A Jane; Lagunes, Leonila; Zebarjedi, Ronak et al. (2017) The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2. J Biol Chem 292:8750-8761
Bohórquez-Hernández, A; Gratton, Enrico; Pacheco, Jonathan et al. (2017) Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains. Biochim Biophys Acta 1862:1481-1490
Malacrida, Leonel; Jameson, David M; Gratton, Enrico (2017) A multidimensional phasor approach reveals LAURDAN photophysics in NIH-3T3 cell membranes. Sci Rep 7:9215
Liu, Kai; Marple, Gary R; Allard, Jun et al. (2017) Dynamics of a multicomponent vesicle in shear flow. Soft Matter 13:3521-3531

Showing the most recent 10 out of 375 publications