Overview Our Virology Core facility provides access to state of the art techniques for research in molecular virology, and thereby expands the capabilities of other Center members by providing them with access to HIV replication assays, siRNA technology, assays for testing the efficiency and sites of action of potential new inhibitors, etc.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM082545-07
Application #
8538428
Study Section
Special Emphasis Panel (ZRG1-AARR-K)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
7
Fiscal Year
2013
Total Cost
$153,624
Indirect Cost
$50,520
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Sanchez, Jacint G; Okreglicka, Katarzyna; Chandrasekaran, Viswanathan et al. (2014) The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer. Proc Natl Acad Sci U S A 111:2494-9
Ren, Jihui; Pei-Chen Lin, Coney; Pathak, Manish C et al. (2014) A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis. Mol Biol Cell 25:712-27
Purdy, Michael D; Bennett, Brad C; McIntire, William E et al. (2014) Function and dynamics of macromolecular complexes explored by integrative structural and computational biology. Curr Opin Struct Biol 27:138-48
Kovalskyy, Dmytro B; Ivanov, Dmitri N (2014) Recognition of the HIV capsid by the TRIM5? restriction factor is mediated by a subset of pre-existing conformations of the TRIM5? SPRY domain. Biochemistry 53:1466-76
Monroe, Nicole; Han, Han; Gonciarz, Malgorzata D et al. (2014) The oligomeric state of the active Vps4 AAA ATPase. J Mol Biol 426:510-25
Ladinsky, Mark S; Kieffer, Collin; Olson, Gregory et al. (2014) Electron tomography of HIV-1 infection in gut-associated lymphoid tissue. PLoS Pathog 10:e1003899
Narayan, Kedar; Danielson, Cindy M; Lagarec, Ken et al. (2014) Multi-resolution correlative focused ion beam scanning electron microscopy: applications to cell biology. J Struct Biol 185:278-84
Hulme, Amy E; Hope, Thomas J (2014) The cyclosporin A washout assay to detect HIV-1 uncoating in infected cells. Methods Mol Biol 1087:37-46
Lamorte, Louie; Titolo, Steve; Lemke, Christopher T et al. (2013) Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes. Antimicrob Agents Chemother 57:4622-31
Votteler, Jorg; Sundquist, Wesley I (2013) Virus budding and the ESCRT pathway. Cell Host Microbe 14:232-41

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