Overview Our Virology Core facility provides access to state of the art techniques for research in molecular virology, and thereby expands the capabilities of other Center members by providing them with access to HIV replication assays, siRNA technology, assays for testing the efficiency and sites of action of potential new inhibitors, etc.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM082545-08
Application #
8728903
Study Section
Special Emphasis Panel (ZRG1-AARR-K)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
8
Fiscal Year
2014
Total Cost
$163,648
Indirect Cost
$55,187
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Bailey, Lucas J; Sheehy, Kimberly M; Dominik, Pawel K et al. (2017) Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. J Mol Biol :
Hammond, John A; Zhou, Li; Lamichhane, Rajan et al. (2017) A Survey of DDX21 Activity During Rev/RRE Complex Formation. J Mol Biol :
Sdano, Matthew A; Fulcher, James M; Palani, Sowmiya et al. (2017) A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife 6:
Kieffer, Collin; Ladinsky, Mark S; Ninh, Allen et al. (2017) Longitudinal imaging of HIV-1 spread in humanized mice with parallel 3D immunofluorescence and electron tomography. Elife 6:
Mamede, João I; Cianci, Gianguido C; Anderson, Meegan R et al. (2017) Early cytoplasmic uncoating is associated with infectivity of HIV-1. Proc Natl Acad Sci U S A 114:E7169-E7178
Lamichhane, Rajan; Hammond, John A; Pauszek 3rd, Raymond F et al. (2017) A DEAD-box protein acts through RNA to promote HIV-1 Rev-RRE assembly. Nucleic Acids Res 45:4632-4641
Monroe, Nicole; Han, Han; Shen, Peter S et al. (2017) Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. Elife 6:
Gu, Mingyu; LaJoie, Dollie; Chen, Opal S et al. (2017) LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Proc Natl Acad Sci U S A 114:E2166-E2175
Freund, Natalia T; Wang, Haoqing; Scharf, Louise et al. (2017) Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Sci Transl Med 9:
Pak, Alexander J; Grime, John M A; Sengupta, Prabuddha et al. (2017) Immature HIV-1 lattice assembly dynamics are regulated by scaffolding from nucleic acid and the plasma membrane. Proc Natl Acad Sci U S A 114:E10056-E10065

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