PROGRAM 2: Oscillatory dynamics: PKA Circadian control as modifiers of mast cell responses. One of the central themes of systems biology is the quantitative analysis of the complex dynamical interactions critical to human health. One important signaling pathway, involving protein kinase A (PKA), mediates the daily changes of light on circadian dynamic control. These oscillations underlie the rhythms in pathologies of cardiovascular disease, cancer, sleep disturbances, depression, and allergic immune responses. In this Program, we will explore the mechanisms of circadian rhythms and dynamic control by PKA and the initiation of allergic immune responses in mammalian mast cells, as well as crosstalk to NFKB mediated inflammation.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM085764-03
Application #
8380337
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
3
Fiscal Year
2012
Total Cost
$513,348
Indirect Cost
$182,157
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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