PROGRAM 1: A temporal signaling code: inflammatory and innate immune responses. Innate immunity is the first line of defense against pathogens but is also coupled to inflammation that initiates the adaptive immune arm. Proper dynamic control of inflammatory and innate immune responses is vital for normal physiological function. Deregulated, or chronic inflammatory conditions are drivers of arthritis, atherosclerosis and many types of cancer. In this Program, we will examine the mechanisms underlying dynamic control in NFκB and IFN signaling, characterize the temporal code, and examine the mechanisms that may decode dynamically coded information to determine biological fate decisions.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM085764-03
Application #
8380351
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
3
Fiscal Year
2012
Total Cost
$512,651
Indirect Cost
$108,127
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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