PROGRAM 2: Oscillatory dynamics: PKA Circadian control as modifiers of mast cell responses. One of the central themes of systems biology is the quantitative analysis of the complex dynamical interactions critical to human health. One important signaling pathway, involving protein kinase A (PKA), mediates the daily changes of light on circadian dynamic control. These oscillations underlie the rhythms in pathologies of cardiovascular disease, cancer, sleep disturbances, depression, and allergic immune responses. In this Program, we will explore the mechanisms of circadian rhythms and dynamic control by PKA and the initiation of allergic immune responses in mammalian mast cells, as well as crosstalk to NFKB mediated inflammation.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM085764-04
Application #
8538442
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
4
Fiscal Year
2013
Total Cost
$511,444
Indirect Cost
$182,407
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Bean, Gordon J; Jaeger, Philipp A; Bahr, Sondra et al. (2014) Development of ultra-high-density screening tools for microbial "omics". PLoS One 9:e85177
Nazarko, Taras Y; Ozeki, Katharine; Till, Andreas et al. (2014) Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy. J Cell Biol 204:541-57
Hossain, Munshi Azad; Johnson, Tracy L (2014) Using yeast genetics to study splicing mechanisms. Methods Mol Biol 1126:285-98
Hui, Ashley; Pinter-Wollman, Noa (2014) Individual variation in exploratory behaviour improves speed and accuracy of collective nest selection by Argentine ants. Anim Behav 93:261-266
Tsimring, Lev S (2014) Noise in biology. Rep Prog Phys 77:026601
Mather, William; Hasty, Jeff; Tsimring, Lev S (2014) Synchronization of degrade-and-fire oscillations via a common activator. Phys Rev Lett 113:128102
Bouslimani, Amina; Sanchez, Laura M; Garg, Neha et al. (2014) Mass spectrometry of natural products: current, emerging and future technologies. Nat Prod Rep 31:718-29
Gorkin, David U; Leung, Danny; Ren, Bing (2014) The 3D genome in transcriptional regulation and pluripotency. Cell Stem Cell 14:762-75
Lee, KiYoung; Sung, Min-Kyung; Kim, Jihyun et al. (2014) Proteome-wide remodeling of protein location and function by stress. Proc Natl Acad Sci U S A 111:E3157-66
Caldwell, Andrew B; Cheng, Zhang; Vargas, Jesse D et al. (2014) Network dynamics determine the autocrine and paracrine signaling functions of TNF. Genes Dev 28:2120-33

Showing the most recent 10 out of 69 publications