PROGRAM 3: Integration of homeostatic and dynamic signals: genotoxic stress responses. Eukaryotic organisms have evolved multiple mechanisms of sensing DNA damage and genotoxic stress. The resulting signals are integrated though a regulatory network that also samples the metabolic health of the cell by involving mitochondrial signaling mediators. By integrating dynamic genotoxic response signals and homeostatic regulatory networks, cells determine a variety of different responses, including the decision to undergo cell death via apoptotic or necroptotic pathways. In this Program, we will employ a systems approach to elucidating the mitochondria-dependent cell death program that is conserved from yeast to mammalian cells.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM085764-04
Application #
8538443
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
4
Fiscal Year
2013
Total Cost
$505,837
Indirect Cost
$87,239
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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