Hypertension (central and/or pulmonary) can be the primary cause of cardiac remodeling leading to heart failure (HF). Yet even in circumstances where the primary efiology of HF is in processes intrinsic to the heart, remodeling of the pump and its electromechanical properties will alter the pressures and flows in the cardiovascular system. So we are reminded that comprehensive understanding of complex cardiovascular disease requires the ability to look at (and probe) the system as a whole.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM094503-05
Application #
8876708
Study Section
Special Emphasis Panel (ZGM1-CBCB-2)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
5
Fiscal Year
2014
Total Cost
$162,199
Indirect Cost
$18,812
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Herum, Kate M; Choppe, Jonas; Kumar, Aditya et al. (2017) Mechanical regulation of cardiac fibroblast profibrotic phenotypes. Mol Biol Cell 28:1871-1882
McClymont, Darryl; Teh, Irvin; Carruth, Eric et al. (2017) Evaluation of non-Gaussian diffusion in cardiac MRI. Magn Reson Med 78:1174-1186
Sturdy, Jacob; Ottesen, Johnny T; Olufsen, Mette S (2017) Modeling the differentiation of A- and C-type baroreceptor firing patterns. J Comput Neurosci 42:11-30
Cooling, Michael T; Nickerson, David P; Nielsen, Poul M F et al. (2016) Modular modelling with Physiome standards. J Physiol 594:6817-6831
Gattoni, Sara; Røe, Åsmund Treu; Frisk, Michael et al. (2016) The calcium-frequency response in the rat ventricular myocyte: an experimental and modelling study. J Physiol 594:4193-224
Dewan, Sukriti; McCabe, Kimberly J; Regnier, Michael et al. (2016) Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study. J Phys Chem B 120:8264-75
Yipintsoi, Tada; Kroll, Keith; Bassingthwaighte, James B (2016) Fractal regional myocardial blood flows pattern according to metabolism, not vascular anatomy. Am J Physiol Heart Circ Physiol 310:H351-64
Tewari, Shivendra G; Gottipati, Manoj K; Parpura, Vladimir (2016) Mathematical Modeling in Neuroscience: Neuronal Activity and Its Modulation by Astrocytes. Front Integr Neurosci 10:3
Neal, Maxwell L; Gennari, John H; Cook, Daniel L (2016) Qualitative causal analyses of biosimulation models. CEUR Workshop Proc 1747:
Tewari, Shivendra G; Bugenhagen, Scott M; Palmer, Bradley M et al. (2016) Dynamics of cross-bridge cycling, ATP hydrolysis, force generation, and deformation in cardiac muscle. J Mol Cell Cardiol 96:11-25

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