An important goal of this proposal is to link the integrated computational modeling of genetic and physiological systems to experimental studies in defined strains. Throughout Projects 1-4, the use of already recently developed models and the generation of several new animal models are proposed. We will use our expertise in rat breeding and high throughput genotyping, rat germline transgenesis, gene knockout, as well as newly developed approaches for gene knockin, as the various projects dictate and as new predictions and testable hypotheses emerge. The selection of the models will be based on several criteria. First and most importantly, is the strain likely to give phenotype information that could be modeled or predicted by the simulation toolsets? Second, is disruption of the gene likely to lead to a viable animal model? We will determine whether a mouse KO model has been successfully produced. Thirdly, is the strain likely to be a valuable model to the research community? In Project 5, the validated simulation tool sets will be combined to understand integrated systems function and different model strains will be likewise combined through breeding to test simulations of the integrated toolsets.
| Williams, Nakeya D; Mehlsen, Jesper; Tran, Hien T et al. (2018) An optimal control approach for blood pressure regulation during head-up tilt. Biol Cybern : |
| Olsen, Christian Haargaard; Ottesen, Johnny T; Smith, Ralph C et al. (2018) Parameter subset selection techniques for problems in mathematical biology. Biol Cybern : |
| Wright, Peter T; Bhogal, Navneet K; Diakonov, Ivan et al. (2018) Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in ?2AR-cAMP Responsiveness in Murine Hearts. Cell Rep 23:459-469 |
| Ciocanel, Maria-Veronica; Docken, Steffen S; Gasper, Rebecca E et al. (2018) Cardiovascular regulation in response to multiple hemorrhages: analysis and parameter estimation. Biol Cybern : |
| Qureshi, M Umar; Colebank, Mitchel J; Schreier, David A et al. (2018) Characteristic impedance: frequency or time domain approach? Physiol Meas 39:014004 |
| Herum, Kate M; Choppe, Jonas; Kumar, Aditya et al. (2017) Mechanical regulation of cardiac fibroblast profibrotic phenotypes. Mol Biol Cell 28:1871-1882 |
| McClymont, Darryl; Teh, Irvin; Carruth, Eric et al. (2017) Evaluation of non-Gaussian diffusion in cardiac MRI. Magn Reson Med 78:1174-1186 |
| Sturdy, Jacob; Ottesen, Johnny T; Olufsen, Mette S (2017) Modeling the differentiation of A- and C-type baroreceptor firing patterns. J Comput Neurosci 42:11-30 |
| Tran, Kenneth; Han, June-Chiew; Taberner, Andrew J et al. (2016) Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension. Am J Physiol Heart Circ Physiol 311:H563-71 |
| Lee, Pilhwa; Wolgemuth, Charles W (2016) Physical Mechanisms of Cancer in the Transition to Metastasis. Biophys J 111:256-66 |
Showing the most recent 10 out of 116 publications
