LIVE IMAGING CORE AND HUB OF INNOVATION Mission The ability to visualize dynamic interactions between bacterial populations and their hosts in live developing animals is an important tool for our proposed Center. The main mission of our Live Imaging Core Facility is to implement advanced microscopy techniques and to develop robust protocols for viewing host-microbe interactions in living animals. Key components are a custom-built light sheet fluorescence microscope and a staff microscopist dedicated to novel instrumentation and to developing new approaches to data analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM098911-02
Application #
8546418
Study Section
Special Emphasis Panel (ZGM1-CBCB-3)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2013
Total Cost
$141,380
Indirect Cost
$43,876
Name
University of Oregon
Department
Type
DUNS #
948117312
City
Eugene
State
OR
Country
United States
Zip Code
97403
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Mason, Timothy; Snell, Kathy; Mittge, Erika et al. (2016) Strategies to Mitigate a Mycobacterium marinum Outbreak in a Zebrafish Research Facility. Zebrafish :
Wiles, Travis J; Jemielita, Matthew; Baker, Ryan P et al. (2016) Host Gut Motility Promotes Competitive Exclusion within a Model Intestinal Microbiota. PLoS Biol 14:e1002517
Hill, Jennifer Hampton; Franzosa, Eric A; Huttenhower, Curtis et al. (2016) A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development. Elife 5:
Milligan-Myhre, Kathryn; Small, Clayton M; Mittge, Erika K et al. (2016) Innate immune responses to gut microbiota differ between oceanic and freshwater threespine stickleback populations. Dis Model Mech 9:187-98
Zac Stephens, W; Burns, Adam R; Stagaman, Keaton et al. (2016) The composition of the zebrafish intestinal microbial community varies across development. ISME J 10:644-54
Preston, Jessica L; Royall, Ariel E; Randel, Melissa A et al. (2016) High-specificity detection of rare alleles with Paired-End Low Error Sequencing (PELE-Seq). BMC Genomics 17:464
Klein, Ann M; Bohannan, Brendan J M; Jaffe, Daniel A et al. (2016) Molecular Evidence for Metabolically Active Bacteria in the Atmosphere. Front Microbiol 7:772
Hammers, Matthew D; Taormina, Michael J; Cerda, Matthew M et al. (2015) A Bright Fluorescent Probe for H2S Enables Analyte-Responsive, 3D Imaging in Live Zebrafish Using Light Sheet Fluorescence Microscopy. J Am Chem Soc 137:10216-23
Stagaman, Keaton; Martinez, Emily S; Guillemin, Karen (2015) Immigrants in immunology: the benefits of lax borders. Trends Immunol 36:286-9

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