LIVE IMAGING CORE AND HUB OF INNOVATION Mission The ability to visualize dynamic interactions between bacterial populations and their hosts in live developing animals is an important tool for our proposed Center. The main mission of our Live Imaging Core Facility is to implement advanced microscopy techniques and to develop robust protocols for viewing host-microbe interactions in living animals. Key components are a custom-built light sheet fluorescence microscope and a staff microscopist dedicated to novel instrumentation and to developing new approaches to data analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM098911-03
Application #
8727614
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Oregon
Department
Type
DUNS #
City
Eugene
State
OR
Country
United States
Zip Code
97403
Leve, Leslie D; Neiderhiser, Jenae M; Harold, Gordon T et al. (2018) Naturalistic Experimental Designs as Tools for Understanding the Role of Genes and the Environment in Prevention Research. Prev Sci 19:68-78
Schlomann, Brandon H (2018) Stationary moments, diffusion limits, and extinction times for logistic growth with random catastrophes. J Theor Biol 454:154-163
Logan, Savannah L; Thomas, Jacob; Yan, Jinyuan et al. (2018) The Vibrio cholerae type VI secretion system can modulate host intestinal mechanics to displace gut bacterial symbionts. Proc Natl Acad Sci U S A 115:E3779-E3787
Ganz, J; Baker, R P; Hamilton, M K et al. (2018) Image velocimetry and spectral analysis enable quantitative characterization of larval zebrafish gut motility. Neurogastroenterol Motil 30:e13351
Massaquoi, Michelle S; Guillemin, Karen (2018) Evolving in a Microbial Soup: You Are What They Eat. Dev Cell 47:682-683
Logan, Savannah L; Dudley, Christopher; Baker, Ryan P et al. (2018) Automated high-throughput light-sheet fluorescence microscopy of larval zebrafish. PLoS One 13:e0198705
Fahimipour, Ashkaan K; Hartmann, Erica M; Siemens, Andrew et al. (2018) Daylight exposure modulates bacterial communities associated with household dust. Microbiome 6:175
Parthasarathy, Raghuveer (2018) Monitoring microbial communities using light sheet fluorescence microscopy. Curr Opin Microbiol 43:31-37
Hay, Edouard A; Parthasarathy, Raghuveer (2018) Performance of convolutional neural networks for identification of bacteria in 3D microscopy datasets. PLoS Comput Biol 14:e1006628
Stagaman, Keaton; Cepon-Robins, Tara J; Liebert, Melissa A et al. (2018) Market Integration Predicts Human Gut Microbiome Attributes across a Gradient of Economic Development. mSystems 3:

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