. Mechanical signals from a cell's microenvironment are known to alter cell behavior and gene expression profiles, but the role of mRNA processing is unclear. The Cell Mechanics Core provides as set of resources that, together with the computational (Core 4) and RNA profiling resources (Cores 1 and 2) in the Center for RNA Systems Biology, will provide a new perspective on the intersection of cell mechanics and gene regulation.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM102706-03
Application #
8733713
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Type
DUNS #
City
Berkeley
State
CA
Country
United States
Zip Code
94704
McGlincy, Nicholas J; Ingolia, Nicholas T (2017) Transcriptome-wide measurement of translation by ribosome profiling. Methods 126:112-129
Jost, Marco; Chen, Yuwen; Gilbert, Luke A et al. (2017) Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell 68:210-223.e6
Iwasaki, Shintaro; Ingolia, Nicholas T (2017) The Growing Toolbox for Protein Synthesis Studies. Trends Biochem Sci 42:612-624
Zubradt, Meghan; Gupta, Paromita; Persad, Sitara et al. (2017) DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo. Nat Methods 14:75-82
Wright, Addison V; Liu, Jun-Jie; Knott, Gavin J et al. (2017) Structures of the CRISPR genome integration complex. Science 357:1113-1118
Lintner, Nathanael G; McClure, Kim F; Petersen, Donna et al. (2017) Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol 15:e2001882
Cate, Jamie H D (2017) Human eIF3: from 'blobology' to biological insight. Philos Trans R Soc Lond B Biol Sci 372:
Kostova, Kamena K; Hickey, Kelsey L; Osuna, Beatriz A et al. (2017) CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. Science 357:414-417
Li, Bo; Tambe, Akshay; Aviran, Sharon et al. (2017) PROBer Provides a General Toolkit for Analyzing Sequencing-Based Toeprinting Assays. Cell Syst 4:568-574.e7
Liu, S John; Horlbeck, Max A; Cho, Seung Woo et al. (2017) CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science 355:

Showing the most recent 10 out of 45 publications