The Biostatistical and Biomechanical Measurements Core (BBMC) will provide biostatistics and biomechanical support to SCOR Projects I, II, and III.
AIM1 is to assist with study design, power analyses and data analysis plans.
AIM 2 is to provide engineering support for experimental, clinical and 3-D imaging measurements.
AIM 3 is to provide support for database management and information exchange across SCOR Projects.
AIM 4 is to conduct high quality statistical analyses across SCOR Projects, and AIM 5 is to provide mentoring and training of young investigators in these methods in conjunction with Core C. Core B will assist with technical aspects of tissue property and quantitative histology measurements in Project 1 (30 cadavers), as well as human subjects measurements (n=60) in Project 1. In Project 11 it will assist with post-natal quantification of pubovisceral muscles and their defects in MR images from up to 88 women. In Project 111 it will assist with measurements of vaginal support using biomechanical instrumentation, standardized 3-D MR images and clinical measurements in up to 100 women. Finally, Core B will continue to foster new academic collaborations and interface with industry partners, developing novel instrumentation and analytical techniques as needed.

Public Health Relevance

The important scientific advances envisioned in this project depend on producing novel data that accurately capture complex physiology. Their appropriate statistical analysis is essential to testing the hypotheses outlined in this proposal. Core B will provide the biomechanical testing and statistical support needed to achieve our goals.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
2P50HD044406-11
Application #
8366610
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q (50))
Project Start
Project End
Budget Start
2012-09-22
Budget End
2013-05-31
Support Year
11
Fiscal Year
2012
Total Cost
$235,349
Indirect Cost
$83,999
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Miller, Janis M; Garcia, Caroline E; Hortsch, Sarah Becker et al. (2016) Does Instruction to Eliminate Coffee, Tea, Alcohol, Carbonated, and Artificially Sweetened Beverages Improve Lower Urinary Tract Symptoms?: A Prospective Trial. J Wound Ostomy Continence Nurs 43:69-79
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Cameron, Anne P; Suskind, Anne M; Neer, Charlene et al. (2015) Functional and anatomical differences between continent and incontinent men post radical prostatectomy on urodynamics and 3T MRI: a pilot study. Neurourol Urodyn 34:527-32
Kim, Jinyong; Betschart, Cornelia; Ramanah, Rajeev et al. (2015) Anatomy of the pubovisceral muscle origin: Macroscopic and microscopic findings within the injury zone. Neurourol Urodyn 34:774-80

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