Core A: Sex Differences Administrative Support Core will be responsible for the following five services to coordinate the three projects in this SCOR.
Aim 1 : Administration: Core A will provide administrative support to Projects 1,11, and 111 for recruitment. subject scheduling, forms generation, IRB issues, organization, and confidential filing. Centralized support will decrease cost and increase effectiveness.
Aim 2 : Human Subjects: Core A will assure ongoing safety of human subjects through active involvement with our IRB committee. This involvement will assure compliance with institutional and national regulations, track and assess subject safety by monitoring adverse events, and provide information to outside subject safety committee (DSMB) as necessary. This core will prepare regular reports from centralized logs from all Projects concerning adverse events to increase detection of infrequent events that require special attention.
Aim 3 : Fostering Sex and Gender Research: Core A will seek to stimulate further research with the following activities: a) convene an annual SCOR sponsored Pelvic Floor Research Day to foster interdisciplinary discussion across campus along with translational partners and mentees, and b) support, maintain, and expand the SCOR Pelvic Floor Disorders Data Bank of over 1,200 research subjects, totaling over 20,000 images from prior and ongoing projects.
Aim 4 : Budget: Core A will manage the fiscal responsibility of Project I, II, and III along with expenses of Cores A, B, and C. This will include assurance of appropriate distribution of funds to support all three projects throughout the entire length of the funding period.
Aim 5 : Presentation and Manuscript Production: Core A will be responsible for the administrative aspects of the dissemination of data and findings to research and clinical practitioners. Manuscripts and presentations will be submitted and tracked through Core A, allowing immediate translation of important sex-differences research to the community of researchers and physicians who can implement changes and improve prevention and treatment.
The strong central organizing activities of this administrative core will facilitate new discoveries that impact interdisciplinary sex-differences research. By promoting and supporting the broadly interdisciplinary U-M SCOR research team, Core A frees individual investigators from some management effort so they may concentrate on important insights needed to improve prevention and treatment for 3 million women giving birth and 300,000 women suffering from pelvic floor disorders.
|Kim, Jinyong; Betschart, Cornelia; Ramanah, Rajeev et al. (2015) Anatomy of the pubovisceral muscle origin: Macroscopic and microscopic findings within the injury zone. Neurourol Urodyn 34:774-80|
|Suskind, Anne M; Dunn, Rodney L; Morgan, Daniel M et al. (2015) A screening tool for clinically relevant urinary incontinence. Neurourol Urodyn 34:332-5|
|Cameron, Anne P; Suskind, Anne M; Neer, Charlene et al. (2015) Functional and anatomical differences between continent and incontinent men post radical prostatectomy on urodynamics and 3T MRI: a pilot study. Neurourol Urodyn 34:527-32|
|Luo, Jiajia; Smith, Tovia M; Ashton-Miller, James A et al. (2014) In vivo properties of uterine suspensory tissue in pelvic organ prolapse. J Biomech Eng 136:021016|
|Low, Lisa Kane; Zielinski, Ruth; Tao, Yebin et al. (2014) Predicting Birth-Related Levator Ani Tear Severity in Primiparous Women: Evaluating Maternal Recovery from Labor and Delivery (EMRLD Study). Open J Obstet Gynecol 4:266-278|
|Yousuf, Aisha; Chen, Luyun; Larson, Kindra et al. (2014) The length of anterior vaginal wall exposed to external pressure on maximal straining MRI: relationship to urogenital hiatus diameter, and apical and bladder location. Int Urogynecol J 25:1349-56|
|Suskind, Anne M; DeLancey, John O L; Hussain, Hero K et al. (2014) Dynamic MRI evaluation of urethral hypermobility post-radical prostatectomy. Neurourol Urodyn 33:312-5|
|Berger, Mitchell B; Morgan, Daniel M; DeLancey, John O (2014) Levator ani defect scores and pelvic organ prolapse: is there a threshold effect? Int Urogynecol J 25:1375-9|
|Stafford, Ryan E; Mazzone, Stuart; Ashton-Miller, James A et al. (2014) Dynamics of male pelvic floor muscle contraction observed with transperineal ultrasound imaging differ between voluntary and evoked coughs. J Appl Physiol (1985) 116:953-60|
|Betschart, Cornelia; Kim, Jinyong; Miller, Janis M et al. (2014) Comparison of muscle fiber directions between different levator ani muscle subdivisions: in vivo MRI measurements in women. Int Urogynecol J 25:1263-8|
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