Growing evidence from multimodal brain imaging studies highlights the importance of a synergistic approach towards characterizing the neurobiological substrate of reading disability (RD). The overall goal of Project 4 (Neuroimaging) is to develop a comprehensive neurobiological model of text comprehension that will supplement the cognitive framework developed within Project 2 (Executive Functions). In addition, we propose to evaluate features of brain organization associate with developmental outcomes of educational interventions addressed in Project 3 (Intervention). Project 4 (Neuroimaging) will address three aims.
The first aim i s to characterize features of brain organization supporting sentence comprehension, using a multiple task and multimodal imaging approach (MEG, quantitative structural MRI and DTI), to identify print- dependent and print-independent neural components of reading comprehension (RC)--the former associated with sentence reading and word recognition, and the latter associated with executive functions (EFs)--in non- impaired readers and in students experiencing text comprehension difficulties.
The second aim i s to examine the predictive value of pre-intervention multimodal imaging data for subsequent response to intervention.
This aim models individual response to educational interventions (Project 3) as a function of aberrant features of the brain organization for comprehension in RD.
The third aim i s to investigate functional changes in brain organization following educational interventions by focusing on adequate and inadequate responders in conjunction with project 1 (Classification). Addressing this aim entails evaluating alternative models of functional brain plasticity in association with successful response to intervention (i.e., normalization vs. compensation). By successfully addressing these aims. Project 4 will promote novel directions in cognitive neuroscience research featuring combinations of several multimodal imaging methods, in order to identify features of brain organization that are crucial for typical development of reading comprehension skills and successful intervention outcomes.

Public Health Relevance

Although much attention has been devoted to neural processes underlying word reading, less is known about the neural correlates of reading comprehension, especially in relation to instructional response and executive functions. Multimodal imaging promises a more comprehensive understanding of the brain mechanisms associated with adequate and inadequate instructional response and the neural correlates of reading comprehension in typically developing and struggling readers.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
4P50HD052117-10
Application #
8989134
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
2017-11-30
Budget Start
2015-12-01
Budget End
2016-11-30
Support Year
10
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Houston
Department
Type
DUNS #
036837920
City
Houston
State
TX
Country
United States
Zip Code
77204
Engelhardt, Laura E; Roe, Mary Abbe; Juranek, Jenifer et al. (2017) Children's head motion during fMRI tasks is heritable and stable over time. Dev Cogn Neurosci 25:58-68
Nikki Arrington, C; Kulesz, Paulina A; Juranek, Jenifer et al. (2017) White matter microstructure integrity in relation to reading proficiency?. Brain Lang 174:103-111
Hodge, David R; Salas-Wright, Christopher P; Vaughn, Michael G (2017) Behavioral Risk Profiles of Homeschooled Adolescents in the United States: A Nationally Representative Examination of Substance Use Related Outcomes. Subst Use Misuse 52:273-285
Williams, Kelly J; Walker, Melodee A; Vaughn, Sharon et al. (2017) A Synthesis of Reading and Spelling Interventions and Their Effects on Spelling Outcomes for Students With Learning Disabilities. J Learn Disabil 50:286-297
Williams, Victoria J; Juranek, Jenifer; Cirino, Paul et al. (2017) Cortical Thickness and Local Gyrification in Children with Developmental Dyslexia. Cereb Cortex :
Taylor, W Pat; Miciak, Jeremy; Fletcher, Jack M et al. (2017) Cognitive discrepancy models for specific learning disabilities identification: Simulations of psychometric limitations. Psychol Assess 29:446-457
Fletcher, Jack M; Miciak, Jeremy (2017) Comprehensive Cognitive Assessments are not Necessary for the Identification and Treatment of Learning Disabilities. Arch Clin Neuropsychol 32:2-7
Gerst, Elyssa H; Cirino, Paul T; Fletcher, Jack M et al. (2017) [Formula: see text]Cognitive and behavioral rating measures of executive function as predictors of academic outcomes in children. Child Neuropsychol 23:381-407
Miciak, Jeremy; Williams, Jacob L; Taylor, W Pat et al. (2016) Do Processing Patterns of Strengths and Weaknesses Predict Differential Treatment Response? J Educ Psychol 108:898-909
Wanzek, Jeanne; Vaughn, Sharon; Scammacca, Nancy et al. (2016) Meta-Analyses of the Effects of Tier 2 Type Reading Interventions in Grades K-3. Educ Psychol Rev 28:551-576

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