The overarching goal of the proposed project is to rigorously test an intervention program for parents and their infants at-risk of an ASD that is developmentally informed, child-centered and focused on joint attention, a core deficit in young children with autism and an important area of concern for at-risk infants. An early intervention research classroom focused on core deficits of Joint Attention, Symbolic Play, Engagement and Regulation (Baby JASPER) will be compared to a hospital based early intervention program that focuses on early motor development, cognition, adaptive and social skills (Baby Standard). Parents will be provided with training in both classrooms and children will receive therapist led intervention sessions and a weekly home visit to practice generalization of skills. This project tests whether a classroom focusing on joint attention and object interest/play facilitates greater social-communication outcomes than a widely used early intervention curriculum focused on broad developmental goals. The project addresses gaps in the 2011 lACC Strategic Plan, including the identification of individual characteristics that predict response to interventions, clinical trials aimed at identifying active ingredients of effective treatments, and identification of biological signatures as related to treatment response. This project has the potential to identify critical intervention elements for young infants at risk for autism. Participants will include 72 infants (aged 12 months to 21 months) and their parents who will be randomized to one of the two classrooms. Treatment will consist of two 3-hour sessions each week plus an additional hour of in-home training over 8 weeks with pre and post assessments and follow-ups at 4, 6 and 12 months to span a 12 month period of the infants'development. Primary outcome measures focus on social-communication and language abilities of the infants with secondary measures of parent interactions and electrophysiological measures to examine biomarkers of change with treatment as well as predictors of social communication outcomes. Since parents play a critical role in their children's development, an effective parent-mediated intervention with a focus on core deficits may result in better language, and ultimately, improved social outcomes for at-risk infants.

Public Health Relevance

The proposed study addresses gaps in our knowledge of early intervention for infants at risk of autism by a) testing the efficacy of an early social communication intervention (Baby JASPER) using a rigorous randomized controlled treatment design, b) intervening on core deficits of early autism, c) mediating intervention through the parent in both clinic and home settings;and (d) intergrating electrophysiological measures to better inform our predictors of outcomes.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
5P50HD055784-08
Application #
8700146
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
8
Fiscal Year
2014
Total Cost
$274,972
Indirect Cost
$96,447
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2016) Salience Network Connectivity in Autism Is Related to Brain and Behavioral Markers of Sensory Overresponsivity. J Am Acad Child Adolesc Psychiatry 55:618-626.e1
Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2016) Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Res :
Shire, Stephanie Y; Gulsrud, Amanda; Kasari, Connie (2016) Increasing Responsive Parent-Child Interactions and Joint Engagement: Comparing the Influence of Parent-Mediated Intervention and Parent Psychoeducation. J Autism Dev Disord 46:1737-47
Gulsrud, Amanda C; Hellemann, Gerhard; Shire, Stephanie et al. (2016) Isolating active ingredients in a parent-mediated social communication intervention for toddlers with autism spectrum disorder. J Child Psychol Psychiatry 57:606-13
DiStefano, Charlotte; Gulsrud, Amanda; Huberty, Scott et al. (2016) Identification of a distinct developmental and behavioral profile in children with Dup15q syndrome. J Neurodev Disord 8:19
Messinger, Daniel S; Young, Gregory S; Webb, Sara Jane et al. (2016) Commentary: sex difference differences? A reply to Constantino. Mol Autism 7:31
Miller, Meghan; Iosif, Ana-Maria; Young, Gregory S et al. (2016) School-age outcomes of infants at risk for autism spectrum disorder. Autism Res 9:632-42
Hutman, Ted; Harrop, Clare; Baker, Elizabeth et al. (2016) Joint engagement modulates object discrimination in toddlers: a pilot electrophysiological investigation. Soc Neurosci 11:525-30
Lee, Ji-Ann; Damianov, Andrey; Lin, Chia-Ho et al. (2016) Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes. Neuron 89:113-28
Jann, Kay; Smith, Robert X; Rios Piedra, Edgar A et al. (2016) Noise Reduction in Arterial Spin Labeling Based Functional Connectivity Using Nuisance Variables. Front Neurosci 10:371

Showing the most recent 10 out of 100 publications