Core C, the Neuroimaging/Neurophysiolgy Core, provides comprehensive services for acquisition, analysis, and integration of brain biomarker data from EEG, MRI, and eye tracking studies. There is a critical need to develop brain biomarkers of autism that are relevant across age ranges and severity level, and that are sensitive for detecting early brain abnormalities, developmental trajectories, and response to treatment. Each of the five Projects in the center will utilize services, resources and expertise provided by Core C to address specific aims and Center themes more generally. The Core will provide four main functions: 1) Subject preparation and desensitization;2) implementing a common set of tasks across projects and modalities;3) data acquisition, and 4) data analysis and integration with projects to address specific aims and facilitate cross-project collaborations. By centralizing these modalities within the same core we can provide a common set of measures, acquired consistently across subjects and methods, allowing us to integrate data in cross- project collaborations. Common tasks will address core themes including language acquisition, implicit (statistic) learning, and social attention. We have access to outstanding infrastructure and equipment resources for acquiring the core measures proposed: these are structural MRI, Diffusion Tensor Imaging (DTI) resting state MRI, functional MRI activation. Resting and activation EEG, eye tracking and pupillometry. The Core provides a team of experts in acquisition and analysis of these data. Further, the core will support several novel approaches to data analysis and integration including graph theoretical approaches to understand brain connectivity networks applied across modalities, and machine learning analytic approaches for predicting outcomes, groups, or phenotypic characteristics. Working in tandem with the statistics unit, the Core personnel will work with project and core investigators to integrate neuroimaging and neurophysiology findings with project-specific data to address both project aims and the ACE central themes.

Public Health Relevance

Core C, the Neuroimaging/Neurophysiology Core, provides acquisition and analysis services for structural and functional MRI, DTI, EEG/ERP, and eye tracking data utilized by all five projects in the Center. Core C provides comprehensive data analysis for these biomarker data including integration with project-specific measures, forming the foundation for cross-project collaborations that are critical to this integrative center.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
5P50HD055784-08
Application #
8700153
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
8
Fiscal Year
2014
Total Cost
$186,646
Indirect Cost
$65,476
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2016) Salience Network Connectivity in Autism Is Related to Brain and Behavioral Markers of Sensory Overresponsivity. J Am Acad Child Adolesc Psychiatry 55:618-626.e1
Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2016) Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Res :
Shire, Stephanie Y; Gulsrud, Amanda; Kasari, Connie (2016) Increasing Responsive Parent-Child Interactions and Joint Engagement: Comparing the Influence of Parent-Mediated Intervention and Parent Psychoeducation. J Autism Dev Disord 46:1737-47
Gulsrud, Amanda C; Hellemann, Gerhard; Shire, Stephanie et al. (2016) Isolating active ingredients in a parent-mediated social communication intervention for toddlers with autism spectrum disorder. J Child Psychol Psychiatry 57:606-13
DiStefano, Charlotte; Gulsrud, Amanda; Huberty, Scott et al. (2016) Identification of a distinct developmental and behavioral profile in children with Dup15q syndrome. J Neurodev Disord 8:19
Messinger, Daniel S; Young, Gregory S; Webb, Sara Jane et al. (2016) Commentary: sex difference differences? A reply to Constantino. Mol Autism 7:31
Miller, Meghan; Iosif, Ana-Maria; Young, Gregory S et al. (2016) School-age outcomes of infants at risk for autism spectrum disorder. Autism Res 9:632-42
Hutman, Ted; Harrop, Clare; Baker, Elizabeth et al. (2016) Joint engagement modulates object discrimination in toddlers: a pilot electrophysiological investigation. Soc Neurosci 11:525-30
Lee, Ji-Ann; Damianov, Andrey; Lin, Chia-Ho et al. (2016) Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes. Neuron 89:113-28
Jann, Kay; Smith, Robert X; Rios Piedra, Edgar A et al. (2016) Noise Reduction in Arterial Spin Labeling Based Functional Connectivity Using Nuisance Variables. Front Neurosci 10:371

Showing the most recent 10 out of 100 publications