Abstract

The objective of the Clinical Core is to facilitate the transfer of clinical data and specimens to the Project Directors' laboratories and to speed the application of basic science discoveries to critically ill patients with acute lung injury. The SCOR Acute Lung Injury Database which is currently enrolling 70 patients per year will continue as a comprehensive of clinical information on the etiology, management and long-term outcome of patients with lung injury. The Database will also link patients' clinical information with tissue specimens obtained through Core B protocols and examined in SCOR investigators' laboratories. As promising new therapies for lung injury are ready to be tested on patient populations, then the clinical core's expertise in human subjects protection and consent procedures; patient recruitment and follow-up; and standardized data collection will permit rapid assessment of clinical efficacy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
2P50HL050152-06
Application #
6110228
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
6
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Larsson, Ola; Perlman, David M; Fan, Danhua et al. (2006) Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure. Nucleic Acids Res 34:4375-86
Li, Shunan; Perlman, David M; Peterson, Mark S et al. (2004) Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis. J Biol Chem 279:21312-7
Lei, Jianxun; Mariash, Cary N; Ingbar, David H (2004) 3,3',5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent. J Biol Chem 279:47589-600
Tian, Bin; Han, Lei; Kleidon, Jill et al. (2003) An HSV-TK transgenic mouse model to evaluate elimination of fibroblasts for fibrosis therapy. Am J Pathol 163:789-801
Lee, So Yeong; Maniak, Peter J; Ingbar, David H et al. (2003) Adult alveolar epithelial cells express multiple subtypes of voltage-gated K+ channels that are located in apical membrane. Am J Physiol Cell Physiol 284:C1614-24
Lei, Jianxun; Nowbar, Sogol; Mariash, Cary N et al. (2003) Thyroid hormone stimulates Na-K-ATPase activity and its plasma membrane insertion in rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 285:L762-72
Li, Shunan; Takasu, Tasaburo; Perlman, David M et al. (2003) Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release. J Biol Chem 278:3015-22
Weinert, Craig R; Gross, Cynthia R; Marinelli, William A (2003) Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals. Am J Respir Crit Care Med 167:1304-9
Hao, Hong; Wendt, Christine H; Sandhu, Gurpreet et al. (2003) Dexamethasone stimulates transcription of the Na+-K+-ATPase beta1 gene in adult rat lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 285:L593-601
Hao, Hong; Rhodes, Richard; Ingbar, David H et al. (2003) Dexamethasone responsive element in the rat Na, K-ATPase beta1 gene coding region. Biochim Biophys Acta 1630:55-63

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