Abstract

The small animal core will provide a centralized facility for the measurement of pulmonary resistance and compliance in anesthetized and ventilated mice, and for the measurement of responsiveness to intravenous acetylcholine. The core will also assist in broncholeveolar lavage and in the inflation, perfusion, and embedding of mouse lungs. The core facility will be equipped with two complete plethysmographic systems, including plethysmographs, pressure transducers, amplifiers, pulmonary mechanics analyzers, and chart recorders, and will be staffed by a full time staff research associate under the direct supervision of the principal investigator. The core will be extensively utilized by 4 of the 6 projects in this proposal, and the existence of a core facility will insure both quality control and rapid dissemination of technical information among these 4 projects. By utilizing existing equipment, and a newly constructed, dedicated small animal laboratory, this centralized facility will obviate the needs to train additional personnel in each project lab, to duplicate expensive equipment, and to set aside space in each laboratory suitable for experiments with live animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL056385-03
Application #
6110651
Study Section
Project Start
1998-09-01
Project End
1999-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Jia, Guiquan; Erickson, Richard W; Choy, David F et al. (2012) Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol 130:647-654.e10
Choy, David F; Modrek, Barmak; Abbas, Alexander R et al. (2011) Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol 186:1861-9
Woodruff, Prescott G; Modrek, Barmak; Choy, David F et al. (2009) T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 180:388-95
Voehringer, David; Stanley, Sarah A; Cox, Jeffery S et al. (2007) Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Exp Parasitol 116:458-66
Atabai, Kamran; Sheppard, Dean; Werb, Zena (2007) Roles of the innate immune system in mammary gland remodeling during involution. J Mammary Gland Biol Neoplasia 12:37-45
Woodruff, Prescott G; Dolganov, Gregory M; Ferrando, Ronald E et al. (2004) Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 169:1001-6
Fahy, John V (2002) Goblet cell and mucin gene abnormalities in asthma. Chest 122:320S-326S
Ordonez, C L; Khashayar, R; Wong, H H et al. (2001) Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 163:517-23
Fahy, J V (2001) Remodeling of the airway epithelium in asthma. Am J Respir Crit Care Med 164:S46-51
Ford, J G; Rennick, D; Donaldson, D D et al. (2001) Il-13 and IFN-gamma: interactions in lung inflammation. J Immunol 167:1769-77

Showing the most recent 10 out of 12 publications