An overall aim of the SCOR is to elucidate mechanisms of airway hyper- reactivity using, in part, animal models. A critical feature of the SCOR is to provide transgenic mice as appropriate models. The transgenic core will provide transgenic animals to the SCOR on either F2 or appropriate inbred mouse backgrounds. It will also provide a ~speed backcrossing~ service whereby DAN polymorphisms will be used to facilitate rapid backcrossing of any given transgene onto an appropriate inbred background. Finally, the core will develop regulated transgenes that permit the expression of given gene products in the airways to be controlled by exogenous manipulation at the will of the investigator.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL056389-03
Application #
6110676
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
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