Abstract

The large bore MRI Core laboratory of this SCOR will provide comprehensive services to the participating investigators regarding quantitative assessment of impaired blood delivery, new vessel development, and functional consequences in large animal (pig) model of angiogenesis and in clinical trials. The primary categories of support will include: 1: in vivo assessment of blood delivery to heart tissue, sensitive to changes over time and response to treatment; 2: in vivo assessment of cardiovascular function, including motion- tracking, partial-volume corrected measures of wall thickness changes, centrifugal endocardial excursion, and ejection fraction; 3: in vivo assessment of microvascular collateral development, based on a new imaging method developed and validated in our laboratory by ex vivo CT, microspheres and histology. The Core will be responsible for MRI scheduling, imaging protocols, image acquisition, quality assurance, image data management and measurements blinded to treatment status, of blood arrival, wall function, and new vessel development in patients and large animal models of ischemic heart disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
1P50HL063609-01
Application #
6320236
Study Section
Special Emphasis Panel (ZHL1-CSR-Y (O1))
Project Start
2000-04-01
Project End
2005-03-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
$219,343
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Wykrzykowska, Joanna J; Rosinberg, Audrey; Lee, Seung U et al. (2011) Autologous cardiomyotissue implantation promotes myocardial regeneration, decreases infarct size, and improves left ventricular function. Circulation 123:62-9
Wu, Guifu; Rana, Jamal S; Wykrzykowska, Joanna et al. (2009) Exercise-induced expression of VEGF and salvation of myocardium in the early stage of myocardial infarction. Am J Physiol Heart Circ Physiol 296:H389-95
Wu, Gui Fu; Wykrzykowska, Joanna J; Rana, Jamal S et al. (2008) Effects of B-type natriuretic peptide (nesiritide) on coronary epicardial arteries, systemic vasculature and microvessels. J Invasive Cardiol 20:76-80
Voisine, Pierre; Rosinberg, Audrey; Wykrzykowska, Joanna J et al. (2008) Skin-derived microorgan autotransplantation as a novel approach for therapeutic angiogenesis. Am J Physiol Heart Circ Physiol 294:H213-9
Post, Mark J; Sato, Kaori; Murakami, Masahiro et al. (2006) Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation. Am J Physiol Regul Integr Comp Physiol 290:R494-500
Tkachenko, Eugene; Rhodes, John M; Simons, Michael (2005) Syndecans: new kids on the signaling block. Circ Res 96:488-500
Abid, Md Ruhul; Yano, Kiichiro; Guo, Shaodong et al. (2005) Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia. J Biol Chem 280:29864-73
Friehs, Ingeborg; Cao-Danh, Hung; Nathan, Meena et al. (2005) Impaired insulin-signaling in hypertrophied hearts contributes to ischemic injury. Biochem Biophys Res Commun 331:15-22
Himes, Nathan; Min, Jian-Yong; Lee, Rebecca et al. (2004) In vivo MRI of embryonic stem cells in a mouse model of myocardial infarction. Magn Reson Med 52:1214-9
Abid, Md Ruhul; Schoots, Ivo G; Spokes, Katherine C et al. (2004) Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. J Biol Chem 279:44030-8

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