Abstract

Pathology Core, will provide histopathology services to all 6 projects in the Central Grant. The services will include routine preparation and histochemistry of paraffin and frozen aortic sections, regular immunostaining, and morphological analysis of the aortic tissue sections by bright field, fluorescence, and confocal microscopy. The Pathology Core also helps each project for morphometry analysis and histopathological sample preparation. In collaboration with other cores, patient's samples will be collected, fixed in formalin, banked, or otherwise stated in each project. Morophological and immunohistochemistry with antibodies against markers for vascular cells and inflammation as well as particular gene products identified by each project will be pursued. Each project will be supplied with a report and photodocumentation of relevant finding.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL083794-05
Application #
8072681
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
5
Fiscal Year
2010
Total Cost
$121,180
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Prakash, Siddharth K; Milewicz, Dianna M (2018) X Marks the Spot: The Profound Impact of Sex on Aortic Disease. Arterioscler Thromb Vasc Biol 38:9-11
Guo, Dong-Chuan; Hostetler, Ellen M; Fan, Yuxin et al. (2017) Heritable Thoracic Aortic Disease Genes in Sporadic Aortic Dissection. J Am Coll Cardiol 70:2728-2730
Ren, Pingping; Hughes, Michael; Krishnamoorthy, Swapna et al. (2017) Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. Sci Rep 7:12351
Wu, Darrell; Ren, Pingping; Zheng, Yanqiu et al. (2017) NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation. Arterioscler Thromb Vasc Biol 37:694-706
Guo, Dong-Chuan; Grove, Megan L; Prakash, Siddharth K et al. (2016) Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections. Am J Hum Genet 99:762-769
Romere, Chase; Duerrschmid, Clemens; Bournat, Juan et al. (2016) Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell 165:566-79
van 't Hof, Femke N G; Ruigrok, Ynte M; Lee, Cue Hyunkyu et al. (2016) Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. J Am Heart Assoc 5:
Prakash, Siddharth; Kuang, Shao-Qing; GenTAC Registry Investigators et al. (2016) Recurrent Rare Genomic Copy Number Variants and Bicuspid Aortic Valve Are Enriched in Early Onset Thoracic Aortic Aneurysms and Dissections. PLoS One 11:e0153543
Starosolski, Zbigniew; Villamizar, Carlos A; Rendon, David et al. (2015) Ultra High-Resolution In vivo Computed Tomography Imaging of Mouse Cerebrovasculature Using a Long Circulating Blood Pool Contrast Agent. Sci Rep 5:10178
Regalado, Ellen S; Guo, Dong-chuan; Prakash, Siddharth et al. (2015) Aortic Disease Presentation and Outcome Associated With ACTA2 Mutations. Circ Cardiovasc Genet 8:457-64

Showing the most recent 10 out of 83 publications