We propose to establish a new educational program in translational research, the Clinical Research Skills Development Core, to address these needs. We have long-recognized the importance of the """"""""team approach"""""""" for attacking the clinical problem of pediatric pulmonary hypertension through the integration of basic scientists from diverse fields with clinician-scientists. In addition to successes in the laboratory and clinical arenas, our program has further provided the environment for mentoring and career development of numerous young clinician-scientists, including 2 of our current project leaders, Drs. Ivy and Kinsella. In the recent past, our NIH SCOR program has further served as an important resource for ongoing NIH T32 training programs in pediatric pulmonary medicine (Dr. Abman;PI) and cardiovascular bioengineering (Dr. Shandas;PI). Thus, the overall goal of the Clinical Research Skills Development Core is to develop a more formal educational and training program in pediatric pulmonary hypertension, which can bring together the strengths of highly collaborative, multidisciplinary investigators, in order to expand our ability to better train young clinician-scientists in translational research. We have outlined a plan to develop new seminars, workshops and training approaches to disease- and patient- oriented research that incorporates experienced investigators from diverse fields. With rapid advances in genetics and genomics, proteomics, outcomes research, and related fields, we plan to bring together major leaders in these fields from within our institution and from other academic health centers. This approach is reflected in the new projects outlined in our current application. For example, Dr. Richard Spritz, the Director of Human Genetics, and Dr. Jill Norris, Head of Genetic Epidemiology, are now, for the first time, actively engaged in the application of their areas of expertise to the problem of pediatric pulmonary hypertension (Project 2). In addition, Dr. Crapo, an active participant in Project 4 will be available to bridge the bench to bedside gap in oxidant research. They will be working with recent K23 awardees or applicants (Drs. Peter Mourani, MD, and Marci Sontag, PhD), along with other senior clinicianscientists in the SCCOR Program. The addition of the Clinical Research Skills Development Core will provide a formal structure to enhance interactions and training opportunities, which will lead to highly-skilled clinical investigators who can better apply numerous skills including genetics and genetic epidemiology to pediatric pulmonary vascular disease. As outlined in the proposal, we plan to provide rigorous training structure to bring together clinician-scientists with leaders in health outcomes research, clinical trial design, clinical physiology, bioinformatics and other fields. To further enhance the training atmosphere, we plan formal workshops in scientific integrity and ethics, communication skills, mentorship, career development, and other critical topics. This program will be co-ordinated by Dr. Abman, who has extensive experience with mentorship and training as Director of the Pediatric Heart Lung Center and the PI of the NIH T32 Program in pediatric pulmonary medicine. He will work closely with Dr. Stenmark, the Project Leaders and collaborating scientists to develop this Core program.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Colorado Denver
United States
Zip Code
Li, Min; Riddle, Suzette; Zhang, Hui et al. (2016) Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1. Circulation 134:1105-1121
Vorhies, Erika E; Ivy, David Dunbar (2014) Drug treatment of pulmonary hypertension in children. Paediatr Drugs 16:43-65
Nicolarsen, Jeremy; Ivy, Dunbar (2014) Progress in the diagnosis and management of pulmonary hypertension in children. Curr Opin Pediatr 26:527-35
Kinsella, John P; Cutter, Gary R; Steinhorn, Robin H et al. (2014) Noninvasive inhaled nitric oxide does not prevent bronchopulmonary dysplasia in premature newborns. J Pediatr 165:1104-1108.e1
Jone, Pei-Ni; Hinzman, Julie; Wagner, Brandie D et al. (2014) Right ventricular to left ventricular diameter ratio at end-systole in evaluating outcomes in children with pulmonary hypertension. J Am Soc Echocardiogr 27:172-8
Takatsuki, Shinichi; Rosenzweig, Erika B; Zuckerman, Warren et al. (2013) Clinical safety, pharmacokinetics, and efficacy of ambrisentan therapy in children with pulmonary arterial hypertension. Pediatr Pulmonol 48:27-34
Takatsuki, Shinichi; Parker, Donna K; Doran, Aimee K et al. (2013) Acute pulmonary vasodilator testing with inhaled treprostinil in children with pulmonary arterial hypertension. Pediatr Cardiol 34:1006-12
Tuder, Rubin M; Archer, Stephen L; Dorfm├╝ller, Peter et al. (2013) Relevant issues in the pathology and pathobiology of pulmonary hypertension. J Am Coll Cardiol 62:D4-12
Su, Zhenbi; Tan, Wei; Shandas, Robin et al. (2013) Influence of distal resistance and proximal stiffness on hemodynamics and RV afterload in progression and treatments of pulmonary hypertension: a computational study with validation using animal models. Comput Math Methods Med 2013:618326
Wagner, Brandie D; Takatsuki, Shinichi; Accurso, Frank J et al. (2013) Evaluation of circulating proteins and hemodynamics towards predicting mortality in children with pulmonary arterial hypertension. PLoS One 8:e80235

Showing the most recent 10 out of 92 publications