The purpose of Core A - Clinical Core is to serve as a resource to the 4 clinical projects (1, 2, 4, 5) of the COPD SCCOR. The Clinical Core will assist in: (1) recruiting subjects;(2) screening of subjects to determine suitability for the projects;(3) carefully phenotyping subjects under clearly defined protocols, once they have been enrolled in the projects;(4) obtaining the relevant biologic materials using fiberoptic bronchoscopy;and (5) working with Core B - the Clinical Operations and Regulatory Affairs (CORA) to ensure all of the studies are done with relevant regulatory / protocol guidelines, and to provide ready access to the clinical phenotyping data. The Clinical Core has extensive experience in both the recruitment and screening, as well as clinical phenotyping of various populations used in numerous clinical research studies. In the 9 months precedingthe submission of this current proposal,a total of 137 individuals have already been assessed and phenotyped for COPD-related clinical research studies through the facilities and resources of the Clinical Core. The Core has access to state-of-theart facilities and equipment with which to carry out procedures, including bronchoscopy, quantitative CT chest scans, and nuclear medicine assessments, integral to phenotyping subjects and obtaining high- quality biologic materials in sufficient quantities for each project. It is staffed by highly qualified physician-scientists with extensive experience in safely conducting bronchoscopies on human research subjects, using previously established methodology for collection of human airway epithelium and alveolar macrophages. As part of these methodologies, the Clinical Core will implement techniques it has more recently established and validated for procurement of airway epithelium from the small airways, as well as obtaining samples over time for assessment of the gene expression pattern in response to brush injury to the airway epithelium, mimicking repair processeswhich may result in the pathologic and physiologic derangements noted in COPD. The Core will devote equal resourcesto Projects 1,2,4 and 5.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL084936-05
Application #
8234984
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2011-01-01
Budget End
2011-12-31
Support Year
5
Fiscal Year
2011
Total Cost
$322,951
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Strulovici-Barel, Yael; Staudt, Michelle R; Krause, Anja et al. (2016) Persistence of circulating endothelial microparticles in COPD despite smoking cessation. Thorax 71:1137-1144
Barjaktarevic, Igor Z; Crystal, Ronald G; Kaner, Robert J (2016) The Role of Interleukin-23 in the Early Development of Emphysema in HIV1(+) Smokers. J Immunol Res 2016:3463104
Harvey, Ben-Gary; Strulovici-Barel, Yael; Kaner, Robert J et al. (2015) Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity. Eur Respir J 46:1589-1597
Gomi, Kazunori; Arbelaez, Vanessa; Crystal, Ronald G et al. (2015) Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS One 10:e0116507
Wang, Guoqing; Wang, Rui; Strulovici-Barel, Yael et al. (2015) Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation. PLoS One 10:e0120824
Walters, Matthew S; De, Bishnu P; Salit, Jacqueline et al. (2014) Smoking accelerates aging of the small airway epithelium. Respir Res 15:94
Hessel, Justina; Heldrich, Jonna; Fuller, Jennifer et al. (2014) Intraflagellar transport gene expression associated with short cilia in smoking and COPD. PLoS One 9:e85453
Shaykhiev, Renat; Crystal, Ronald G (2014) Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells. Ann Am Thorac Soc 11 Suppl 5:S252-8
Brekman, Angelika; Walters, Matthew S; Tilley, Ann E et al. (2014) FOXJ1 prevents cilia growth inhibition by cigarette smoke in human airway epithelium in vitro. Am J Respir Cell Mol Biol 51:688-700
Gao, Chuan; Tignor, Nicole L; Salit, Jacqueline et al. (2014) HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors. Bioinformatics 30:369-76

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