The successful sequencing of the human genome, and the evolution of human health services research, hasproduced an era of unprecedented growth in the knowledge base of the molecular and physiological basis ofhuman diseases. The abundance of high throughput genetic and genomic technologies and the rapidspread of information dictated by exponential increase in computing power and communication technologyare transforming the practice of clinical medicine and clinical research. The recently developed NIHRoadmap makes clear the importance of clinical research and addresses the ways in which clinical researchneeds to be transformed to keep pace with laboratory, genetic, and especially genomic research and toensure that findings are tested and effectively translated into improvements in health and health care. Themain objective of this Clinical Research Skills Development Core (CRSDC) is to provide a structured,intensive research experience for physicians, physician-scientists, or scientists trainees to foster thedevelopment of skills needed to pursue a successful career in investigative clinical research in the study ofchronic obstructive lung disease (COPD). We will utilize a multidisciplinary approach, focusing on thefunctional genomics of human COPD. CRSDC described here addresses this challenge by providing anintegrated training program for junior investigators. In keeping within the guidelines of this Core, we willinclude trainees at postdoctoral fellow or junior faculty up to their K award training period.The CRSDC has the following specific aims:
Specific Aim 1 : To offer a core curriculum that integrates clinical research skills with hands-ongenomics and bioinformatics training using existing programs at the University of Pittsburgh.
Specific Aim 2 : To develop a cross-disciplinary mentoring system that will allow junior investigatorsto develop their research skills and to become independent and productive clinical investigators.
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