The University of Pittsburgh SCORR in COPD builds upon our long tradition of research in Chronic Obstructive Pulmonary Disease to propose a four project proposal which extends our previous work and our strong collaboration with the University of British Columbia. In project 1 PERIPHERAL MARKERS OF PHENOTYPIC HETEROGENEITY IN COPD;Our global hypothesis: COPD is a heterogeneous group of definable anatomic and physiologic disease processes, each with its own molecular and cellular processes that determine disease manifestation and progression;this will be tested in a well characterized cohort of 800 patients. In project 2 ADAPTIVE IMMUNE-INDUCED AIRWA INJURY IN COPD, we postulate that adaptive immune processes, driven by cognate recognition and responses to peptide antigens, cause or contribute to the airway injuries that result in COPD progression;this will be tested largely in human lung explants. In project 3 EGR-1: REGULATOR OF APOPTOSIS AND INFLAMMATION IN COPD we will translate results from human tissue experiments into mouse models to determine whether early growth response (EGR-1), regulates the coordinated expression of apoptosis and inflammation pathways in the context of cigarette smoke-induced chronic obstructive pulmonary disease (COPD). In project 4 CLINICAL INVESTIGATION OF AEROSOL IMMUNOTHERAPY IN COPD we hypothesize that modulation of identified immune responses in COPD subjects with specific biologic agents will ablate or ameliorate pathogenic mechanisms and alter the natural history of COPD.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-A (M1))
Program Officer
Punturieri, Antonello
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Gu, Suicheng; Meng, Xin; Sciurba, Frank C et al. (2014) Bidirectional elastic image registration using B-spline affine transformation. Comput Med Imaging Graph 38:306-14
Fitzpatrick, Meghan E; Tedrow, John R; Hillenbrand, Maria E et al. (2014) Pneumocystis jirovecii colonization is associated with enhanced Th1 inflammatory gene expression in lungs of humans with chronic obstructive pulmonary disease. Microbiol Immunol 58:202-11
Bon, Jessica; Kahloon, Rehan; Zhang, Yingze et al. (2014) Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers. PLoS One 9:e105066
Gingo, Matthew R; He, Jiayan; Wittman, Catherine et al. (2014) Contributors to diffusion impairment in HIV-infected persons. Eur Respir J 43:195-203
Gu, Suicheng; Leader, Joseph; Zheng, Bin et al. (2014) Direct assessment of lung function in COPD using CT densitometric measures. Physiol Meas 35:833-45
Pu, Jiantao; Wang, Zhimin; Gu, Suicheng et al. (2014) Pulmonary fissure integrity and collateral ventilation in COPD patients. PLoS One 9:e96631
Vuga, Louis J; Tedrow, John R; Pandit, Kusum V et al. (2014) C-X-C motif chemokine 13 (CXCL13) is a prognostic biomarker of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 189:966-74
Kundu, Shinjini; Gu, Suicheng; Leader, Joseph K et al. (2013) Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT. Eur Radiol 23:1564-72
Bon, Jessica; Liao, Serena; Tseng, George et al. (2013) Considerations and pitfalls in phenotyping and reclassification of chronic obstructive pulmonary disease. Transl Res 162:252-7
Coxson, Harvey O (2013) Sources of variation in quantitative computed tomography of the lung. J Thorac Imaging 28:272-9

Showing the most recent 10 out of 68 publications