The primary objective of the Clinical Core (CC) is to provide patient access and quality data collection including quantitative radiologic analysis to support the SCCOR in COPD at the University of Pittsburgh. To achieve these objectives, the research proposed will accomplish the following specific aims: A1. To access our diverse well characterized patient populations to efficiently recruit subjects for Projects 1 and 4 and maintain accessibility to tissue for Project 2. A2. To successfully assist in the execution of complex protocols, data collection and transfer of data to the ITBC core. A3. To apply quantitative computed tomography to the phenotypic characterization of subjects with COPD and to longitudinal assessment of disease progression and outcome. This CORE is ideally positioned to meet these goals because it combines the strengths of collaborators with a past history of productivity in subject recruitment, and state of the art clinical, physiologic and quantitative radiographic characterization. It will ensure access to the well-characterized cohorts of the 3700 subjects of the Pittsburgh Lung Screening Study (PLuSS) and Emphysema COPD Research Center (ECRC) and its strong track record of contribution to 7 NHLBI funded clinical research contracts. In addition it will leverage off of access to the infrastructures of the NHLBI sponsored LTRC and the University of Pittsburgh Tissue Resource as well as a very active lung transplantation program to ensure access to high quality lung tissue.
The third aim of this CORE extends the collaboration of the Radiology Research Group at the University of Pittsburgh and the Whole body Imaging Core of the (CAPTURE Centre to create a force with an international reputation in quantitative imaging who are each long term collaborators with Dr. Sciurba. We propose an iterative interaction between the clinical researchers on this project and the powerful imaging team. The preliminary data presented in project 1 and expanded upon in the clinical core reveal the existing structure and the strength of the existing collaboration and confirms the strong potential of this approach in meeting our goals of creating a new classification system for COPD in project 1, and offering innovative strategy for patient selection and outcome assessment in the context of disease modifying interventions such as in our project 4.
|Radder, Josiah E; Zhang, Yingze; Gregory, Alyssa D et al. (2017) Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. Am J Respir Crit Care Med 196:159-171|
|de-Torres, Juan P; Wilson, David O; Sanchez-Salcedo, Pablo et al. (2015) Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD Lung Cancer Screening Score. Am J Respir Crit Care Med 191:285-91|
|Wilson, David O (2015) Sedation Options for Endobronchial Ultrasound-guided Transbronchial Needle Aspiration. Am J Respir Crit Care Med 192:397-8|
|Sze, Marc A; Utokaparch, Soraya; Elliott, W Mark et al. (2015) Loss of GD1-positive Lactobacillus correlates with inflammation in human lungs with COPD. BMJ Open 5:e006677|
|Sanchez-Salcedo, Pablo; Wilson, David O; de-Torres, Juan P et al. (2015) Improving selection criteria for lung cancer screening. The potential role of emphysema. Am J Respir Crit Care Med 191:924-31|
|Thalanayar, Prashanth M; Altintas, Nejat; Weissfeld, Joel L et al. (2015) Indolent, Potentially Inconsequential Lung Cancers in the Pittsburgh Lung Screening Study. Ann Am Thorac Soc 12:1193-6|
|Bon, Jessica; Kahloon, Rehan; Zhang, Yingze et al. (2014) Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers. PLoS One 9:e105066|
|Gu, Suicheng; Meng, Xin; Sciurba, Frank C et al. (2014) Bidirectional elastic image registration using B-spline affine transformation. Comput Med Imaging Graph 38:306-14|
|Gingo, Matthew R; He, Jiayan; Wittman, Catherine et al. (2014) Contributors to diffusion impairment in HIV-infected persons. Eur Respir J 43:195-203|
|Vuga, Louis J; Tedrow, John R; Pandit, Kusum V et al. (2014) C-X-C motif chemokine 13 (CXCL13) is a prognostic biomarker of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 189:966-74|
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