Abstract

The long-term objective of the ITBC is to provide advanced information technology and skilled expertise in metric modeling and biostatistics to support the SSCOR in COPD at the University of Pittsburgh. This Information Technology (IT) system will allow basic and clinical research findings to be organized in a quality-controlled, data mart to permit analyses, pharmacometric modeling, and statistical analyses to support all of the projects included within this proposal. The research proposal will accomplish the following specific aims in order to achieve stated objectives.
Specific Aim 1 : To provide comprehensive IT support to all investigators, all projects (especially project 1, 2, and 3), and all cores in this proposal.
Specific Aim 2 : To provide statistical and mathematical modeling capabilities to all projects (especially intensive for project 1 and project 3) in this proposal.
Specific Aim 3 : To develop novel methods for data mining and online-analytical processing for all projects in this proposal. The proposed ITBC is being built from an existing core resource from within the Center for Clinical Pharmacology, University of Pittsburgh. The current resource at the Center for Clinical Pharmacology has extensive experience and is capable of supporting a number of NIH-funded projects. The Center's capabilities permit a well-established, fully functional, essential clinical research infrastructure support system to be immediately available to the SSCOR in COPD at the University of Pittsburgh.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL084948-05
Application #
8374436
Study Section
Special Emphasis Panel (ZHL1-CSR-A)
Project Start
Project End
2013-12-31
Budget Start
2012-01-01
Budget End
2012-12-31
Support Year
5
Fiscal Year
2012
Total Cost
$274,328
Indirect Cost
$77,998

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Ajala, Oluremi; Zhang, Yingze; Gupta, Aman et al. (2018) Decreased serum TRAIL is associated with increased mortality in smokers with comorbid emphysema and coronary artery disease. Respir Med 145:21-27
Radder, Josiah E; Zhang, Yingze; Gregory, Alyssa D et al. (2017) Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. Am J Respir Crit Care Med 196:159-171
de-Torres, Juan P; Wilson, David O; Sanchez-Salcedo, Pablo et al. (2015) Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD Lung Cancer Screening Score. Am J Respir Crit Care Med 191:285-91
Wilson, David O (2015) Sedation Options for Endobronchial Ultrasound-guided Transbronchial Needle Aspiration. Am J Respir Crit Care Med 192:397-8
Sanchez-Salcedo, Pablo; Wilson, David O; de-Torres, Juan P et al. (2015) Improving selection criteria for lung cancer screening. The potential role of emphysema. Am J Respir Crit Care Med 191:924-31
Sze, Marc A; Utokaparch, Soraya; Elliott, W Mark et al. (2015) Loss of GD1-positive Lactobacillus correlates with inflammation in human lungs with COPD. BMJ Open 5:e006677
Thalanayar, Prashanth M; Altintas, Nejat; Weissfeld, Joel L et al. (2015) Indolent, Potentially Inconsequential Lung Cancers in the Pittsburgh Lung Screening Study. Ann Am Thorac Soc 12:1193-6
Bon, Jessica; Kahloon, Rehan; Zhang, Yingze et al. (2014) Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers. PLoS One 9:e105066
Gu, Suicheng; Meng, Xin; Sciurba, Frank C et al. (2014) Bidirectional elastic image registration using B-spline affine transformation. Comput Med Imaging Graph 38:306-14
Gingo, Matthew R; He, Jiayan; Wittman, Catherine et al. (2014) Contributors to diffusion impairment in HIV-infected persons. Eur Respir J 43:195-203

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