CVD Genetic Predispositions and Genomic Signatures Principal Investigator: Cam Patterson, MD, MBA Cardiovascular diseases (CVD) are the most common cause of morbidity and mortality in the US, accounting for 1/2 of all deaths and health care expenditures. Their incidence is magnified in minority populations and in lower socioeconomic strata. Our proposed clinical research plan targets the cardiovascular diseases that disproportionately afflict underserved and disadvantaged North Carolinians, utilizing a systems approach to develop models that will integrate clinical data with datasets derived from clinical genomics and other inductive, highly detailed methods. To this end, we have developed an approach we refer to as the SAMARA (Supporting A Multidisciplinary Approach to Research in Atherosclerosis) Project that applies recent, major advances in biomedical and computational sciences at UNC to develop deeper understanding of human CVD. Using a combination of high-throughput data collection and computational data mining and model building, we have tested this systems approach on 200 subjects at high risk for CVD. We identified a large number of genes that were both differentially expressed between American subjects self-identified to be of either African or European ancestry and that also contained single nucleotide polymorphisms that distinguish distantly related ancestral populations. Having established and tested this integrative approach, we are now prepared to expand our studies into the community by using this methodology to: 1). Determine the prevalence of genomic risk signatures in high-risk community populations using genome-wide SNP analysis;2). Develop novel genomic models incorporating high-risk features in this population;3). Determine whether genomic signatures can be used to predict responsiveness to interventions that underiie CVD disparities.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL105184-05
Application #
8689142
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Jilcott Pitts, Stephanie B; Keyserling, Thomas C; Johnston, Larry F et al. (2017) Examining the Association between Intervention-Related Changes in Diet, Physical Activity, and Weight as Moderated by the Food and Physical Activity Environments among Rural, Southern Adults. J Acad Nutr Diet 117:1618-1627
Halladay, Jacqueline R; Donahue, Katrina E; Cené, Crystal W et al. (2017) The association of health literacy and blood pressure reduction in a cohort of patients with hypertension: The heart healthy lenoir trial. Patient Educ Couns 100:542-549
Thayer, Linden M; Pimentel, Daniela C; Smith, Janice C et al. (2017) Eating Well While Dining Out: Collaborating with Local Restaurants to Promote Heart Healthy Menu Items. Am J Health Educ 48:11-21
Cené, Crystal W; Halladay, Jacqueline R; Gizlice, Ziya et al. (2017) A multicomponent quality improvement intervention to improve blood pressure and reduce racial disparities in rural primary care practices. J Clin Hypertens (Greenwich) 19:351-360
Keyserling, Thomas C; Samuel-Hodge, Carmen D; Pitts, Stephanie Jilcott et al. (2016) A community-based lifestyle and weight loss intervention promoting a Mediterranean-style diet pattern evaluated in the stroke belt of North Carolina: the Heart Healthy Lenoir Project. BMC Public Health 16:732
Chatterjee, Avik; Daftary, Genevieve; Gatison, Lenward et al. (2016) Lessons Learned From a Partnership to Evaluate a School Food Program. Prog Community Health Partnersh 10:577-584
Cummings, Doyle M; Wu, Jia-Rong; Cene, Crystal et al. (2016) Perceived Social Standing, Medication Nonadherence, and Systolic Blood Pressure in the Rural South. J Rural Health 32:156-63
Hohl, Sarah D; Thompson, Beti; Krok-Schoen, Jessica L et al. (2016) Characterizing Community Health Workers on Research Teams: Results From the Centers for Population Health and Health Disparities. Am J Public Health 106:664-70
Thornton, Rachel L J; Glover, Crystal M; Cené, Crystal W et al. (2016) Evaluating Strategies For Reducing Health Disparities By Addressing The Social Determinants Of Health. Health Aff (Millwood) 35:1416-23
Smith, Caren E; Fullerton, Stephanie M; Dookeran, Keith A et al. (2016) Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities. Health Aff (Millwood) 35:1367-73

Showing the most recent 10 out of 20 publications