We have analyzed cross sectional data from the Prospective Cohort of Older Puerto Ricans for the effects of proximity to major roadways and density of traffic near their residences. This analysis did not assess levels of pollution because the cohort study was not originally designed to assess this exposure. Still, using traffic as a proxy, we have demonstrated associations between traffic proximity and hypertension, blood pressure, C-reactive protein and serum albumin. To oiu- knowledge this is the first study to assess traffic exposure and cardiovascular disease (CVD) markers in a Puerto Rican population, a population that has high prevalence of risk factors and cardiovascular diseases. There is competing evidence that fine particulate matter (PM2.5) is associated with CVD. However, this fraction of PM is spread fairly evenly across geographic areas with variation within cities, but little increase next to heavy traffic. Ultrafine particulate pollution (UFP), which are extremely small particles have, however, been shown to be elevated locally near highways and heavily traveled roadways. Research besides ours also has shown associations between proximity to traffic and CVD. Thus, we will address both the role of traffic pollution in health disparities in the Puerto Rican population and develop evidence about whether there is a causal link between UFP and CVD. We propose three community-based participatory research studies that actively engage our community partners in the research process. Study one will build on our preliminary work and develop a model of UFP exposure across our study area in order to test associations of ambient UFP exposure with CVD in the core cohort (project 1 for the center). Study two will install HEPA air filtration in homes of 20 participants in the core cohort and assess whether reducing UFP in the home is associated with improvements in markers of inflammation, including C-reactive protein, IL6, fibrinogen and TNF-a. Study three will develop and disseminate educational materials about traffic-related pollution and CVD to the local Puerto Rican population.

Public Health Relevance

This study addresses the public health impact of traffic-related air pollution on the development of cardiovascular disease in older Puerto Rican adults. By better understanding the magnitude ofthe risk and a potential intervention, the study may, in the long term, contribute to reducing CVD in this population.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL105185-03
Application #
8377801
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
2013-08-31
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
3
Fiscal Year
2013
Total Cost
$267,607
Indirect Cost
$54,881
Name
Northeastern University
Department
Type
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115
Zheng, Ju-Sheng; Lai, Chao-Qiang; Parnell, Laurence D et al. (2014) Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits. BMC Genomics 15:781
Konstantinidou, Valentini; Ruiz, Lidia Angeles Daimiel; Ordovás, Jose M (2014) Personalized nutrition and cardiovascular disease prevention: From Framingham to PREDIMED. Adv Nutr 5:368S-71S
Dashti, Hassan S; Smith, Caren E; Lee, Yu-Chi et al. (2014) CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. Chronobiol Int 31:660-7
Berkowitz, Seth A; Gao, Xiang; Tucker, Katherine L (2014) Food-insecure dietary patterns are associated with poor longitudinal glycemic control in diabetes: results from the Boston Puerto Rican Health study. Diabetes Care 37:2587-92
Arévalo, Sandra P; Tucker, Katherine L; Falcón, Luis M (2014) Life events trajectories, allostatic load, and the moderating role of age at arrival from Puerto Rico to the US mainland. Soc Sci Med 120:301-10
Brugge, Doug; Reisner, Ellin; Padro-Martinez, Luz T et al. (2013) In-home air filtration for improving cardiovascular health: lessons from a CBPR study in public housing. Prog Community Health Partnersh 7:49-56
Ye, Xingwang; Scott, Tammy; Gao, Xiang et al. (2013) Mediterranean diet, healthy eating index 2005, and cognitive function in middle-aged and older Puerto Rican adults. J Acad Nutr Diet 113:276-81.e1-3
Mattei, Josiemer; Bhupathiraju, Shilpa; Tucker, Katherine L (2013) Higher adherence to a diet score based on American Heart Association recommendations is associated with lower odds of allostatic load and metabolic syndrome in Puerto Rican adults. J Nutr 143:1753-9
Van Rompay, Maria I; McKeown, Nicola M; Castaneda-Sceppa, Carmen et al. (2013) Carbohydrate nutrition differs by diabetes status and is associated with dyslipidemia in Boston Puerto Rican adults without diabetes. J Nutr 143:182-8
Todorova, Irina L G; Tucker, Katherine L; Jimenez, Marcia Pescador et al. (2013) Determinants of self-rated health and the role of acculturation: implications for health inequalities. Ethn Health 18:563-85

Showing the most recent 10 out of 21 publications