Biological markers are needed to capture the impact of living environment, and accumulated psychosocial stress, along v^dth effects of health behaviors, including diet and exercise on functional declines and disabilities associated with aging. The main objective of this core is to provide laboratory support to all projects.
The specific aims ofthe core are to process, analjrze and interpret blood and urinary measures for each ofthe projects. The core will receive blood samples from the field staff, prepare them for analysis and distribute to appropriate labs for analysis or storage. Blood analysis of CBC, lipid profile, glycosylated hemoglobin, albumin, creatinine, C-reactive protein, and serum DHEA-S are performed. Nutritional measures include plasma vitamin (carotenes, folate, vitamin B6, vitamin B12, 25-hydroxy vitamin D) concentrations and metabolic markers (homocysteine). We will also perform genetic analysis for candidate genes in the Genetics Laboratory. Finally, we will analyze urine samples for urinary Cortisol, epinephrine and norepinephrine excretion in the Clinical and Translational Research Center (CTTRC). Each ofthe coordinated proposed projects integrates into the program at least some of these dietary, hematologic and genetic measurements. These functions will be performed for all five projects.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL105185-03
Application #
8377808
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
2013-08-31
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
3
Fiscal Year
2013
Total Cost
$267,603
Indirect Cost
$54,880
Name
Northeastern University
Department
Type
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115
Zheng, Ju-Sheng; Lai, Chao-Qiang; Parnell, Laurence D et al. (2014) Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits. BMC Genomics 15:781
Konstantinidou, Valentini; Ruiz, Lidia Angeles Daimiel; Ordovás, Jose M (2014) Personalized nutrition and cardiovascular disease prevention: From Framingham to PREDIMED. Adv Nutr 5:368S-71S
Dashti, Hassan S; Smith, Caren E; Lee, Yu-Chi et al. (2014) CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. Chronobiol Int 31:660-7
Berkowitz, Seth A; Gao, Xiang; Tucker, Katherine L (2014) Food-insecure dietary patterns are associated with poor longitudinal glycemic control in diabetes: results from the Boston Puerto Rican Health study. Diabetes Care 37:2587-92
Arévalo, Sandra P; Tucker, Katherine L; Falcón, Luis M (2014) Life events trajectories, allostatic load, and the moderating role of age at arrival from Puerto Rico to the US mainland. Soc Sci Med 120:301-10
Brugge, Doug; Reisner, Ellin; Padro-Martinez, Luz T et al. (2013) In-home air filtration for improving cardiovascular health: lessons from a CBPR study in public housing. Prog Community Health Partnersh 7:49-56
Ye, Xingwang; Scott, Tammy; Gao, Xiang et al. (2013) Mediterranean diet, healthy eating index 2005, and cognitive function in middle-aged and older Puerto Rican adults. J Acad Nutr Diet 113:276-81.e1-3
Mattei, Josiemer; Bhupathiraju, Shilpa; Tucker, Katherine L (2013) Higher adherence to a diet score based on American Heart Association recommendations is associated with lower odds of allostatic load and metabolic syndrome in Puerto Rican adults. J Nutr 143:1753-9
Van Rompay, Maria I; McKeown, Nicola M; Castaneda-Sceppa, Carmen et al. (2013) Carbohydrate nutrition differs by diabetes status and is associated with dyslipidemia in Boston Puerto Rican adults without diabetes. J Nutr 143:182-8
Todorova, Irina L G; Tucker, Katherine L; Jimenez, Marcia Pescador et al. (2013) Determinants of self-rated health and the role of acculturation: implications for health inequalities. Ethn Health 18:563-85

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