Our goal is to create a transdisciplinary research center that improves cardiovascular outcomes and reduces racial and ethnic disparities in care in Baltimore, Maryland. We will use community-based participatory research principles to build strong ties among researchers, healthcare provider networks, community members, and policy-makers. We are building on prior work and established relationships with the large African American population in Baltimore, and we will initially focus on hypertension. The Center will Include 3 separate but related intervention studies to improve the identification, treatment, and outcomes of African Americans with hypertension;3 integrated and complimentary Cores;an Internal Steering Committee;and a Community and Provider Advisory Board. Study 1 is a pragmatic clinical trial that examines the implementation of a multi-method quality improvement intervention in 6 community-based primary care practices. Study 2 is a randomized controlled trial to test the effectiveness and long-term sustainability of self-management and problem-solving training for patients, family and community members. Study 3 is a 3-arm randomized controlled trial of culturally-tailored nutritional advice and a mineral supplement containing potassium, magnesium, and Vitamin C. Primary outcomes for all 3 studies are systolic and diastolic blood pressure and blood pressure control. The Administrative Core will carry out the overall administration of the grant, guiding and coordinating shared resources and training activities and managing the Center's studies. The Shared Resources Core will provide infrastructure and support for study design, database development, data management and analysis, patient recruitment and retention, intervention development, standardization of measurements and dissemination of results for the Center Projects and Administrative and Training Cores. The Training Core will provide transdisciplinary training and mentorship in health disparities for pre-doctoral, post-doctoral, junior faculty, and established faculty in the Schools of Medicine, Public Health, and Nursing.

Public Health Relevance

Racial disparities in hypertension prevalence, control, and related cardiovascular (CVD) complications and mortality, are persistent and extensively documented. Despite strong evidence for the efficacy of pharmacologic and lifestyle therapies in African Americans and whites, blood pressure control rates remain suboptimal, even among persons receiving regular health care. There is an urgent need to comprehensively integrate the best evidence-based sustainable, multi-level strategies to overcome hvoertension disparities

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-SRLB-3 (J1))
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Kaufmann, Peter G
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Johns Hopkins University
Internal Medicine/Medicine
Schools of Medicine
United States
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Cooper, Lisa A; Purnell, Tanjala S; Ibe, Chidinma A et al. (2016) Reaching for Health Equity and Social Justice in Baltimore: The Evolution of an Academic-Community Partnership and Conceptual Framework to Address Hypertension Disparities. Ethn Dis 26:369-78
Hussain, Tanvir; Franz, Whitney; Brown, Emily et al. (2016) The Role of Care Management as a Population Health Intervention to Address Disparities and Control Hypertension: A Quasi-Experimental Observational Study. Ethn Dis 26:285-94
Miller 3rd, Edgar R; Cooper, Lisa A; Carson, Kathryn A et al. (2016) A Dietary Intervention in Urban African Americans: Results of the ""Five Plus Nuts and Beans"" Randomized Trial. Am J Prev Med 50:87-95
Smith, Caren E; Fullerton, Stephanie M; Dookeran, Keith A et al. (2016) Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities. Health Aff (Millwood) 35:1367-73
Kan, Athena Wing-ga; Hussain, Tanvir; Carson, Kathryn A et al. (2015) The Contribution of Age and Weight to Blood Pressure Levels Among Blacks and Whites Receiving Care in Community-Based Primary Care Practices. Prev Chronic Dis 12:E161
Siddiqui, Mona; Cooper, Lisa A; Appel, Lawrence J et al. (2015) Recruitment and enrollment of African Americans and Caucasians in a health promotion trial for persons with serious mental illness. Ethn Dis 25:72-7
Hayward, Erin; Ibe, Chidinma; Young, Jeffery Hunter et al. (2015) Linking social and built environmental factors to the health of public housing residents: a focus group study. BMC Public Health 15:351
Hararah, Mohammad Khalid; Pollack, Craig Evan; Garza, Mary A et al. (2015) The Relationship Between Education and Prostate-Specific Antigen Testing Among Urban African American Medicare Beneficiaries. J Racial Ethn Health Disparities 2:176-83
Hussain, Tanvir; Allen, Allyssa; Halbert, Jennifer et al. (2015) Provider perspectives on essential functions for care management in the collaborative treatment of hypertension: the P.A.R.T.N.E.R. framework. J Gen Intern Med 30:454-61
Cooper, Lisa A; Ortega, Alexander N; Ammerman, Alice S et al. (2015) Calling for a bold new vision of health disparities intervention research. Am J Public Health 105 Suppl 3:S374-6

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