This project is to build and develop a Tobacco Regulation and Addiction Center at the American Heart Association (AHA). This virtual Center will be a network of consortia between AHA and several leading academic institutions. It will house programs of multidisciplinary research that will inform the manufacture, distribution and marketing of tobacco products related to the regulatory authority of the FDA. Center investigators will study the cardiovascular toxicity of tobacco products and the relationship between tobacco product use and subclinical progression of cardiovascular disease to identify sensitive and robust biomarkers of cardiovascular injury related to tobacco product exposure. These studies will help to identify the relative sensitivity of specific domains of cardiovascular injury that are sensitive to tobacco exposure and facilitate the identification of harmful and potentially harmful constituents of current, new and emerging tobacco products that cause cardiovascular injury and how the impact of these constituents on cardiovascular disease outcomes could be measured. In cohorts of varying ethnicities, behavior, perceptions, and attitudes regarding tobacco products will be studied to identify which communications channels are used by vulnerable populations to obtain information about tobacco products, and which strategies are likely to be effective in discouraging initiation and continuation of tobacco use. The Center will also provide comprehensive education, state-of-the-art training in tobacco regulatory science and foster the development of independent research careers of junior investigators. Research in the Center will be supported by facilities/cores that will provide assessments and characterization of exposure to tobacco products and unified measurements of biomarkers and validated indices of cardiovascular injury. The administrative core of the Center will provide scientific, administrative and logistic oversight to all aspects of the Center and coordinate integrative team science focused on addressing the research priorities of the FDA. The Center will be well-poised to undertake strong and coordinated research projects in response to new developments and conduct collaborative research with other Centers in the Tobacco Centers of Regulatory Science.

Public Health Relevance

Research supported by the AHA-Tobacco Regulation and Addiction Center (A-TRAC) will aid the development and evaluation of tobacco product regulation by the FDA and thereby contribute to the protection of public health and reduction of tobacco-related disease, disability and death.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Postow, Lisa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
American Heart Association
United States
Zip Code
Fox, Caroline S; Hwang, Shih-Jen; Nieto, Kenneth et al. (2016) Digital Connectedness in the Framingham Heart Study. J Am Heart Assoc 5:e003193
Bhatnagar, Aruni (2016) Cardiovascular Perspective of the Promises and Perils of E-Cigarettes. Circ Res 118:1872-5
Wu, Yangfeng; Benjamin, Emelia J; MacMahon, Stephen (2016) Prevention and Control of Cardiovascular Disease in the Rapidly Changing Economy of China. Circulation 133:2545-60
Campion, MaryAnn W; Bhasin, Robina M; Beaudette, Donald J et al. (2016) Mid-career faculty development in academic medicine: How does it impact faculty and institutional vitality? J Fac Dev 30:49-64
Conklin, Daniel J; Haberzettl, Petra; Jagatheesan, Ganapathy et al. (2016) Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein. Toxicol Appl Pharmacol :
Vasan, Ramachandran S; Benjamin, Emelia J (2016) The Future of Cardiovascular Epidemiology. Circulation 133:2626-33
Conklin, Daniel J (2016) Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1. Ann N Y Acad Sci 1374:59-67
Rahman, Faisal; Yin, Xiaoyan; Larson, Martin G et al. (2016) Trajectories of Risk Factors and Risk of New-Onset Atrial Fibrillation in the Framingham Heart Study. Hypertension 68:597-605
Lee, Jane J; Yin, Xiaoyan; Hoffmann, Udo et al. (2016) Relation of Pericardial Fat, Intrathoracic Fat, and Abdominal Visceral Fat With Incident Atrial Fibrillation (from the Framingham Heart Study). Am J Cardiol 118:1486-1492
Fetterman, Jessica L; Holbrook, Monica; Westbrook, David G et al. (2016) Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease. Cardiovasc Diabetol 15:53

Showing the most recent 10 out of 16 publications