This project is to build and develop a Tobacco Regulation and Addiction Center at the American Heart Association (AHA). This virtual Center will be a network of consortia between AHA and several leading academic institutions. It will house programs of multidisciplinary research that will inform the manufacture, distribution and marketing of tobacco products related to the regulatory authority of the FDA. Center investigators will study the cardiovascular toxicity of tobacco products and the relationship between tobacco product use and subclinical progression of cardiovascular disease to identify sensitive and robust biomarkers of cardiovascular injury related to tobacco product exposure. These studies will help to identify the relative sensitivity of specific domains of cardiovascular injury that are sensitive to tobacco exposure and facilitate the identification of harmful and potentially harmful constituents of current, new and emerging tobacco products that cause cardiovascular injury and how the impact of these constituents on cardiovascular disease outcomes could be measured. In cohorts of varying ethnicities, behavior, perceptions, and attitudes regarding tobacco products will be studied to identify which communications channels are used by vulnerable populations to obtain information about tobacco products, and which strategies are likely to be effective in discouraging initiation and continuation of tobacco use. The Center will also provide comprehensive education, state-of-the-art training in tobacco regulatory science and foster the development of independent research careers of junior investigators. Research in the Center will be supported by facilities/cores that will provide assessments and characterization of exposure to tobacco products and unified measurements of biomarkers and validated indices of cardiovascular injury. The administrative core of the Center will provide scientific, administrative and logistic oversight to all aspects of the Center and coordinate integrative team science focused on addressing the research priorities of the FDA. The Center will be well-poised to undertake strong and coordinated research projects in response to new developments and conduct collaborative research with other Centers in the Tobacco Centers of Regulatory Science.

Public Health Relevance

Research supported by the AHA-Tobacco Regulation and Addiction Center (A-TRAC) will aid the development and evaluation of tobacco product regulation by the FDA and thereby contribute to the protection of public health and reduction of tobacco-related disease, disability and death.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Postow, Lisa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
American Heart Association
United States
Zip Code
Conklin, Daniel J; Haberzettl, Petra; Jagatheesan, Ganapathy et al. (2017) Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein. Toxicol Appl Pharmacol 324:61-72
Bhatnagar, Aruni (2017) Are Electronic Cigarette Users at Increased Risk for Cardiovascular Disease? JAMA Cardiol 2:237-238
Tibuakuu, Martin; Kamimura, Daisuke; Kianoush, Sina et al. (2017) The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study. PLoS One 12:e0184914
Kianoush, Sina; Bittencourt, Marcio S; Lotufo, Paulo A et al. (2017) Association Between Smoking and Serum GlycA and High-Sensitivity C-Reactive Protein Levels: The Multi-Ethnic Study of Atherosclerosis (MESA) and Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Am Heart Assoc 6:
Al Rifai, Mahmoud; DeFilippis, Andrew P; McEvoy, John W et al. (2017) The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 258:119-130
Conklin, Daniel J; Malovichko, Marina V; Zeller, Iris et al. (2017) Biomarkers of Chronic Acrolein Inhalation Exposure in Mice: Implications for Tobacco Product-Induced Toxicity. Toxicol Sci 158:263-274
Ogunwale, Mumiye A; Li, Mingxiao; Ramakrishnam Raju, Mandapati V et al. (2017) Aldehyde Detection in Electronic Cigarette Aerosols. ACS Omega 2:1207-1214
Abplanalp, Wesley; DeJarnett, Natasha; Riggs, Daniel W et al. (2017) Benzene exposure is associated with cardiovascular disease risk. PLoS One 12:e0183602
Leigh, J Adam; Kaplan, Robert C; Swett, Katrina et al. (2017) Smoking intensity and duration is associated with cardiac structure and function: the ECHOcardiographic Study of Hispanics/Latinos. Open Heart 4:e000614
Li, Wenyuan; Dorans, Kirsten S; Wilker, Elissa H et al. (2017) Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study. Arterioscler Thromb Vasc Biol 37:1793-1800

Showing the most recent 10 out of 56 publications