Our plans for this Center for the Neuroscience of Mental disorders (CNMD) with a focus on schizophrenia, represent an extension of the present NIMH-funded Center for Neuroscience and Schizophrenia (CNS). The proposed Center continues to exploit the numerous collaborative interactions that exist within the large community of basic and clinical neuroscientists on campus. The general goals of the proposed CNMD are to investigate the involvement of prefrontal cortex in the pathophysiology of schizophrenia by testing the following main hypothesis: Prefrontal cortical dysfunction in schizophrenia is related to a reduction in dopaminergic activity in this region, and to diminished activity in glutamatergic projection neurons. The Center will consist of three cores, one Administrative (Director, E. Stricker), one Clinical (Director, N. Schooler), and the third Statistical (Director, R. Pagano), and four major research programs. Proposed Project 5 (Prefrontal Cortical Regulation of Nucleus Accumbens; Directors, E. Stricker, M. Zigmond) extends research that had been contained in Project 2 of the CNS; its main focus is on the influence of glutamatergic corticofugal fibers on mesolimbic dopamine neurons. Proposed Project 6 (Synapses and their Modulation in the Prefrontal Cortex; Directors, G. Barrionuevo, F. Crepel) is a new project that evolved from Project 1 in the CNS; its main focus is on the relation between structure and function in prefrontal cortical neurons, and the modulatory influence of monoaminergic input on those neurons. Proposed Project 2 (Organization of Primate Prefrontal Cortical Circuitry; Directors, D. Lewis, J. Lund, R. Moore) is a continuation of Project 3 in the CNS; its main focus is on the functional architecture of neuronal circuits in the prefrontal cortex of monkeys and of homologous cortical areas in brains of schizophrenics and normal human controls. Proposed Project 7 (The Role of Prefrontal Cortex in the Cognitive Dysfunctions of Schizophrenia; Directors, J. McClelland, J. Cohen) is another new project; its main goal is to understand the cognitive functions subserved by prefrontal cortex in humans, and their impairment in schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH045156-05
Application #
2246430
Study Section
Neuroscience Subcommittee (MHSP)
Project Start
1990-04-01
Project End
1998-06-30
Budget Start
1994-07-01
Budget End
1995-06-30
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Other Basic Sciences
Type
Schools of Arts and Sciences
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Cai, HuaLin; Zhou, Xiang; Dougherty, George G et al. (2018) Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia. Psychoneuroendocrinology 90:43-51
Stevenson, J M; Reilly, J L; Harris, M S H et al. (2016) Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. Transl Psychiatry 6:e739
Lizano, Paulo L; Keshavan, Matcheri S; Tandon, Neeraj et al. (2016) Angiogenic and immune signatures in plasma of young relatives at familial high-risk for psychosis and first-episode patients: A preliminary study. Schizophr Res 170:115-22
Horton, Leslie E; Tarbox, Sarah I; Olino, Thomas M et al. (2015) Trajectories of premorbid childhood and adolescent functioning in schizophrenia-spectrum psychoses: A first-episode study. Psychiatry Res 227:339-46
Bishop, Jeffrey R; Reilly, James L; Harris, Margret S H et al. (2015) Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia. Psychopharmacology (Berl) 232:145-54
Hall, Nathan; Colby, Carol (2014) S-cone visual stimuli activate superior colliculus neurons in old world monkeys: implications for understanding blindsight. J Cogn Neurosci 26:1234-56
Subramanian, Janani; Colby, Carol L (2014) Shape selectivity and remapping in dorsal stream visual area LIP. J Neurophysiol 111:613-27
Berdyyeva, Tamara K; Olson, Carl R (2014) Intracortical microstimulation of supplementary eye field impairs ability of monkeys to make serially ordered saccades. J Neurophysiol 111:1529-40
Lencer, Rebekka; Bishop, Jeffrey R; Harris, Margret S H et al. (2014) Association of variants in DRD2 and GRM3 with motor and cognitive function in first-episode psychosis. Eur Arch Psychiatry Clin Neurosci 264:345-55
Richard, Annette E; Carter, Cameron S; Cohen, Jonathan D et al. (2013) Persistence, diagnostic specificity and genetic liability for context-processing deficits in schizophrenia. Schizophr Res 147:75-80

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