The main goal of the proposed CRC is to evaluate the clinical utility of two major forms of psychotherapy: cognitive therapy and dynamic therapy. Four disorders will be initially studied: chronic depression, generalized anxiety disorder, and two personality disorders (avoidant and obsessive compulsive). In the first phase of the CRC, six pilot/training projects employing cognitive therapy and dynamic therapy for each of the disorders will be implemented. These pilot projects will allow for trying out new treatment manuals, training therapists, and standardizing procedures across investigators. A seventh pilot project will examine the reformulated learned helplessness theory using a chronic depression population. In the second phase of the CRC, clinical trials (submitted as R01s) comparing the two psychotherapies and standard pharmacotherapy for these disorders will be performed using the therapists trained in the pilot phase. Two additional training/pilot studies focusing on cognitive and dynamic therapies for Dependent Personality Disorder will be performed in years 4 - 5. A final pilot study in years 3 - 5 will pursue the possibility of integrating a brief cognitive therapy based training program with psychodynamic therapy for major depression. In addition, the CRC will support the lines of research in existing ROls, including method development and predictive studies. The current ROls, future ROls, and pilot projects are supported by four integrated cores: 1. Administration, 2. Therapeutics and Training, 3. Assessment and Accrual, and 4. Data Management and Statistics. The CRC will also promote the training of new investigators in this field.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
3P50MH045178-05S1
Application #
2246449
Study Section
Special Emphasis Panel (SRCM (10))
Project Start
1990-07-01
Project End
1996-06-30
Budget Start
1994-07-01
Budget End
1996-06-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Mooney, Tessa Katherine; Gibbons, Mary Beth Connolly; Gallop, Robert et al. (2014) Psychotherapy credibility ratings: patient predictors of credibility and the relation of credibility to therapy outcome. Psychother Res 24:565-77
Crits-Christoph, Paul; Gibbons, Mary Beth Connolly; Hamilton, Jessica et al. (2011) The dependability of alliance assessments: the alliance-outcome correlation is larger than you might think. J Consult Clin Psychol 79:267-78
Crits-Christoph, Paul; Gibbons, Mary Beth Connolly; Temes, Christina M et al. (2010) Interpersonal accuracy of interventions and the outcome of cognitive and interpersonal therapies for depression. J Consult Clin Psychol 78:420-8
Stulz, Niklaus; Crits-Christoph, Paul (2010) Distinguishing anxiety and depression in self-report: purification of the Beck Anxiety Inventory and Beck Depression Inventory-II. J Clin Psychol 66:927-40
Tu, X M; Kowalski, J; Crits-Christoph, P et al. (2006) Power analyses for correlations from clustered study designs. Stat Med 25:2587-606
Strauss, Jennifer L; Hayes, Adele M; Johnson, Sheri L et al. (2006) Early alliance, alliance ruptures, and symptom change in a nonrandomized trial of cognitive therapy for avoidant and obsessive-compulsive personality disorders. J Consult Clin Psychol 74:337-45
Tu, X M; Kowalski, J; Zhang, J et al. (2004) Power analyses for longitudinal trials and other clustered designs. Stat Med 23:2799-815
Kowalski, J; Tu, X M; Jia, G et al. (2003) Generalized covariance-adjusted canonical correlation analysis with application to psychiatry. Stat Med 22:595-610
Luborsky, L; Stuart, J; Friedman, S et al. (2001) The Penn Psychoanalytic Treatment Collection: a set of complete and recorded psychoanalyses as a research resource. J Am Psychoanal Assoc 49:217-34

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