We describe a mature multi-site IDSC, """"""""Early Experiences, Stress, and Neurodevelopment"""""""" focused on understanding the impacts of early life stress (ELS). We use ELS as a framework to encompass adverse early care conditions: separation/loss, neglect, abuse. We integrate basic developmental behavioral neuroscience using various models to a) increase understanding of the behavioral and neurobiological impacts of ELS, b) identify care experiences that support recovery, and c) approach these questions guided by preventive intervention researchers so that future interventions can benefit from this more comprehensive knowledge base. In 3 projects we test the hypothesis that adverse conditions of early caregiving result in chronic activation of neurohormonal stress systems, shapes more reactive threat response system functioning, and impacts the development of cortico-limbic attention- and emotion regulatory systems. These neural systems are plastic during early life;improved care can normalize their functioning. However, because young children exposed to these ELS conditions often confront caregivers with disordered attachment behaviors &disruptive behavior problems, therapeutic parenting must provide nurturance the child needs but may not signal, and reduce behavior problems through firm, non-hostile, structure/limit-setting. Even so, children exposed to the most severe, prolonged ELS may sustain neurodevelopmental vulnerabilities that increase risk of pathology long after care conditions improve. Our projects involve (1) young children in domestic foster care (2) those adopted from orphanages overseas, as well as (3) another model that allows random assignment to maltreating care and tracking of neurodevelopmental impacts in ways not feasible with young children. The work is supported by 5 Cores: Administrative, Behavioral Coding, Neuropsychological/ Electrophysiological, Data Management, and Assay. We use behavioral observations, electrophysiology (EEG, ERPs, EMG, ECG), neuroendocrine activity (HPA axis) under basal conditions and in response to psychological &pharmacological challenges, in vivo neuroimaging (MRI, DTI, MRS), and neurobehavioral tasks of amygdala (fear-potentiated startle) &prefrontal functioning. Our Center also includes a cross-training program in basic developmental science and developmental psychopathology &prevention science.

Public Health Relevance

Children who experience early adversity are at significant risk for emotional and cognitive problems. We integrate work on toddlers in foster care, toddlers adopted from orphanages, and Rhesus infants abused by their mothers to understand how these experiences affect the development of brain systems involved in emotion and attention. We also focus on types of parenting that helps neurobehavioral recovery.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH078105-05
Application #
8440823
Study Section
Special Emphasis Panel (ZMH1-ERB-L (04))
Program Officer
Zehr, Julia L
Project Start
2009-03-01
Project End
2015-02-28
Budget Start
2013-03-01
Budget End
2015-02-28
Support Year
5
Fiscal Year
2013
Total Cost
$1,808,594
Indirect Cost
$179,840
Name
University of Minnesota Twin Cities
Department
Pediatrics
Type
Schools of Education
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Olson, Anneke E; Kim, Hyoun K; Bruce, Jacqueline et al. (2018) General Cognitive Ability as an Early Indicator of Problem Behavior Among Toddlers in Foster Care. J Dev Behav Pediatr :
Zhang, Shu; Jiang, Xi; Zhang, Wei et al. (2018) Joint representation of connectome-scale structural and functional profiles for identification of consistent cortical landmarks in macaque brain. Brain Imaging Behav :
Wakeford, Alison G P; Morin, Elyse L; Bramlett, Sara N et al. (2018) A review of nonhuman primate models of early life stress and adolescent drug abuse. Neurobiol Stress 9:188-198
Drury, Stacy S; Howell, Brittany R; Jones, Christopher et al. (2017) Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation. Dev Psychopathol 29:1539-1551
Zhang, Wei; Jiang, Xi; Zhang, Shu et al. (2017) Connectome-scale functional intrinsic connectivity networks in macaques. Neuroscience 364:1-14
Frenkel, Tahl I; Koss, Kalsea J; Donzella, Bonny et al. (2017) ADHD Symptoms in Post-Institutionalized Children Are Partially Mediated by Altered Frontal EEG Asymmetry. J Abnorm Child Psychol 45:857-869
Jankowski, Kathryn F; Bruce, Jacqueline; Beauchamp, Kathryn G et al. (2017) Preliminary evidence of the impact of early childhood maltreatment and a preventive intervention on neural patterns of response inhibition in early adolescence. Dev Sci 20:
Lawler, Jamie M; Koss, Kalsea J; Gunnar, Megan R (2017) Bidirectional effects of parenting and child behavior in internationally adopting families. J Fam Psychol 31:563-573
Howell, Brittany R; McMurray, Matthew S; Guzman, Dora B et al. (2017) Maternal buffering beyond glucocorticoids: impact of early life stress on corticolimbic circuits that control infant responses to novelty. Soc Neurosci 12:50-64
Nese, Rhonda N T; Anderson, Cynthia M; Ruppert, Traci et al. (2016) Effects of a video feedback parent training program during child welfare visitation. Child Youth Serv Rev 71:266-276

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