Statistical Genetics Core The Statistical Genetics Core will provide support to Projects I, II, and III to quantify interactions between the Val66Met polymorphism in the Brain Derived Neurotropic Factor (BDNF) gene and experience (stress, trauma, enrichment) on different forms of learning across development. More specifically, the Statistical Genetics Core will consult on all statistical aspects of the project, perform power calculations and simulations to guide experimental design, and perform statistical analyses and hypothesis testing of the final data. These data include both morphological and functional measurements using MRI as well as behavioral assays. The statistical analyses of behavioral and brain imaging data will quantify hippocampal, amygdala, and prefrontal structure and learning-related functions throughout development as a function of genotype (Center Aims 1 &2) and stress (Center Aim 2). In accord with the overarching goals of this Center, this core will consider the interactions between these factors (genotype, development, stress) using appropriate statistical models. We will apply similar analyses to mouse model data, considering the genotype, stress, and enrichment manipulations (Center Aims 1, 2, 3). Finally, in addition to these support functions, the Statistical Genetics Core will be involved in activities relating to the Center's Educational Initiative. The Ithaca contribution will include a training component, giving students and post-docs an opportunity to learn statistical techniques relevant to the Center. Core personnel will provide lectures and workshops on genetic processing at the annual Center meeting orientation and training workshops and at the Sackler Summer Institute for graduate students, postdoctoral fellows, research assistants and other individuals interested in the work of the Center and the area of developmental science and disabilities.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
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Special Emphasis Panel (ZMH1-ERB-A)
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Weill Medical College of Cornell University
New York
United States
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Proenca, Catia C; Song, Minseok; Lee, Francis S (2016) Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors. J Neurochem 138:397-406
Pitula, Clio E; Wenner, Jennifer A; Gunnar, Megan R et al. (2016) To trust or not to trust: social decision-making in post-institutionalized, internationally adopted youth. Dev Sci :
Zhou, Yan; Huang, Ted; Lee, Francis et al. (2016) Involvement of Endocannabinoids in Alcohol ""Binge"" Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists. Alcohol Clin Exp Res 40:467-73
Lee, T T-Y; Hill, M N; Lee, F S (2016) Developmental regulation of fear learning and anxiety behavior by endocannabinoids. Genes Brain Behav 15:108-24
Pattwell, Siobhan S; Liston, Conor; Jing, Deqiang et al. (2016) Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories. Nat Commun 7:11475
Glatt, Charles E; Lee, Francis S (2016) Common Polymorphisms in the Age of Research Domain Criteria (RDoC): Integration and Translation. Biol Psychiatry 79:25-31
Dincheva, Iva; Lynch, Niccola B; Lee, Francis S (2016) The Role of BDNF in the Development of Fear Learning. Depress Anxiety 33:907-916
Johnson, D C; Casey, B J (2015) Easy to remember, difficult to forget: the development of fear regulation. Dev Cogn Neurosci 11:42-55
Song, Minseok; Giza, Joanna; Proenca, Catia C et al. (2015) Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling. Dev Cell 33:690-702
Hodel, Amanda S; Hunt, Ruskin H; Cowell, Raquel A et al. (2015) Duration of early adversity and structural brain development in post-institutionalized adolescents. Neuroimage 105:112-9

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