The central theme of the application for a Boston Center for Intervention Development and Applied Research (CIDAR) is """"""""Vulnerability to Progression in Schizophrenia"""""""". We see two major strengths of the proposal. First we study subjects who are at various stages of progression of the disorder, prodromal, first episode and chronic, giving us a broad perspective and large database on phenotypic markers and predictors of progression. Moreover, prodromes and first episode individuals will be evaluated in a prospective longitudinal study. A second major strength, in our view, is our plan to link clinical, cognitive, neuroimaging, electrophysiological, hormonal and genetic markers of SZ disease progression to the understanding of how the underlying neural circuits may be disturbed. We do this by investigating the expression of genes of interest in specific cellular populations in post-mortem material and evaluating genetic association of the relevant genes with progression indices from each Project. Four projects, each with an experienced investigator as PI, all evaluate the same group of subjects so as to bring multiple perspectives on the markers and predictors of progression. Project 1. """"""""Functional anatomy of neurocognitive deterioration in schizophrenia"""""""", uses neuropsychological and fMRI evaluations. Project 2, """"""""Hormones, memory &sex effects in illness progression in schizophrenia"""""""", evaluates hormones and gender differences in schizophrenia. Project 3, """"""""Electrophysiological and MRI gray matter markers and predictors of progression"""""""", uses event-related potentials (ERPs) and MRI gray matter measures to evaluate progression, often conjoint, in these two domains. Project 4, """"""""Vulnerability to white matter progression in schizophrenia"""""""" uses diffusion tensor imaging evaluations of white matter. A long-standing history of previous successful collaborations and work on joint projects by these project PIs will facilitate the synergistic interactions essential for knitting together data from the different methodological and conceptual domains. The Center mechanism brings added value to this work since no single R01 award could support: 1) the translational gene expression and genetics endeavor in the cores that specifically links to each Project's clinical research findings;2) the large-scale subject recruiting needed for each project;3) the extensive neuroimaging work;4) the linking together of the Project's diverse technologies and levels of analysis on the same subjects, affording a rich opportunity to understand interrelationships of findings from different domains.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH080272-05
Application #
8136034
Study Section
Special Emphasis Panel (ZMH1-ERB-A (01))
Program Officer
Hillefors, MI
Project Start
2007-09-20
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2011
Total Cost
$1,838,585
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Addington, Jean; Piskulic, Danijela; Liu, Lu et al. (2017) Comorbid diagnoses for youth at clinical high risk of psychosis. Schizophr Res 190:90-95
Seitz, Johanna; Sawyer, Kayle S; Papadimitriou, George et al. (2017) Alcoholism and sexual dimorphism in the middle longitudinal fascicle: a pilot study. Brain Imaging Behav 11:1006-1017
Seitz, Johanna; Rathi, Yogesh; Lyall, Amanda et al. (2017) Alteration of gray matter microstructure in schizophrenia. Brain Imaging Behav :
Konishi, Jun; Del Re, Elisabetta C; Bouix, Sylvain et al. (2017) Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: a pilot study. Brain Imaging Behav :
Saito, Yukiko; Kubicki, Marek; Koerte, Inga et al. (2017) Impaired white matter connectivity between regions containing mirror neurons, and relationship to negative symptoms and social cognition, in patients with first-episode schizophrenia. Brain Imaging Behav :
Seitz, Johanna; Zuo, Jessica X; Lyall, Amanda E et al. (2016) Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia. Schizophr Bull 42:762-71
Franke, Barbara; Stein, Jason L; Ripke, Stephan et al. (2016) Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci 19:420-431
Lee, Sang-Hyuk; Niznikiewicz, Margaret; Asami, Takeshi et al. (2016) Initial and Progressive Gray Matter Abnormalities in Insular Gyrus and Temporal Pole in First-Episode Schizophrenia Contrasted With First-Episode Affective Psychosis. Schizophr Bull 42:790-801
Stowkowy, Jacqueline; Liu, Lu; Cadenhead, Kristin S et al. (2016) Core Schemas in Youth at Clinical High Risk for Psychosis. Behav Cogn Psychother 44:203-13
Piskulic, Danijela; Liu, Lu; Cadenhead, Kristin S et al. (2016) Social cognition over time in individuals at clinical high risk for psychosis: Findings from the NAPLS-2 cohort. Schizophr Res 171:176-81

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