This application for an Autism Center of Excellence requests five years of support for an interdisciplinary program of research on behavioral, brain and molecular aspects of the autism spectrum disorders (ASD). It builds on longstanding programmatic research focused on early mechanisms of socialization and their disruption in ASD, on their neurodevelopmental implications for brain structure and function, and on genetic and cytogenetic etiologies associated with social disorders. This application consists of 5 projects and 3 cores. Projects I, II, and III focus on the same cohort of 12- to 24-month-old infants with ASD and their outcome at 36- to 48-months of age. Their objectives include quantification of visual scanning behavior in the context of naturalistic social situations, gaze processing, and auditory preferences associated with the acquisition of language and communicative skills. A byproduct of these studies is the development of performance-based screeners for ASD in the second year of life. Project 4 uses MRI to study indices of structural and functional connectivity in a cohort of 10-year-olds who have been followed-up longitudinally since the age of 24 months through our CPEA and STAART grants. Project 5 focuses on the identification of rare genetic variants contributing to ASDs as a means of discovering molecular pathways involved in these disorders. It leverages the exceedingly well characterized cohort of infants recruited under projects I to III, builds upon our groups'recent findings implicating both cytogenetic abnormalities and sequence mutations in Contactin and Contactin associated family of molecules in developmental disorders, and capitalizes on independent results by collaborators at UCLA suggesting increased risk for ASD resulting from a common haplotype in one of these molecules. The 5 projects are integrated and supported through proven governance and communication provided by an Administrative Core. An Assessment Core will ensure well- characterized subjects in our tradition of clinical excellence and methodological rigor. A Data Analytic and Methodology Core will provide ongoing consultation on study design and data analysis, and collaborate on Center-wide data mining and methodological innovations. The Yale ACE addresses several key action items of the NIH Interagency Autism Coordinating Committee, including neuro-developmental markers and screening in infants, function-specific neural circuitry, and genetic causes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH081756-03
Application #
7808788
Study Section
Special Emphasis Panel (ZHD1-MRG-C (16))
Program Officer
Gilotty, Lisa
Project Start
2008-04-01
Project End
2013-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
3
Fiscal Year
2010
Total Cost
$2,440,136
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Macari, Suzanne L; Koller, Judah; Campbell, Daniel J et al. (2017) Temperamental markers in toddlers with autism spectrum disorder. J Child Psychol Psychiatry 58:819-828
Moriuchi, Jennifer M; Klin, Ami; Jones, Warren (2017) Mechanisms of Diminished Attention to Eyes in Autism. Am J Psychiatry 174:26-35
Szatmari, Peter; Chawarska, Katarzyna; Dawson, Geraldine et al. (2016) Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions. J Am Acad Child Adolesc Psychiatry 55:179-87
Chawarska, Katarzyna; Ye, Saier; Shic, Frederick et al. (2016) Multilevel Differences in Spontaneous Social Attention in Toddlers With Autism Spectrum Disorder. Child Dev 87:543-57
Shic, Frederick (2016) Eye Tracking as a Behavioral Biomarker for Psychiatric Conditions: The Road Ahead. J Am Acad Child Adolesc Psychiatry 55:267-8
Chawarska, Katarzyna; Chang, Joseph; Campbell, Daniel (2015) In Reply. J Am Acad Child Adolesc Psychiatry 54:958-9
Kim, So Hyun; Macari, Suzanne; Koller, Judah et al. (2015) Examining the phenotypic heterogeneity of early Autism Spectrum Disorder: subtypes and short-term outcomes. J Child Psychol Psychiatry :
Klintwall, Lars; Macari, Suzanne; Eikeseth, Svein et al. (2015) Interest level in 2-year-olds with autism spectrum disorder predicts rate of verbal, nonverbal, and adaptive skill acquisition. Autism 19:925-33
Campbell, Daniel J; Shic, Frederick; Macari, Suzanne et al. (2014) Gaze response to dyadic bids at 2 years related to outcomes at 3 years in autism spectrum disorders: a subtyping analysis. J Autism Dev Disord 44:431-42
Ventola, Pamela; Saulnier, Celine A; Steinberg, Elizabeth et al. (2014) Early-emerging social adaptive skills in toddlers with autism spectrum disorders: an item analysis. J Autism Dev Disord 44:283-93

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