Abstract

In this project we will evaluate whether the microstructural properties of white matter connections in the brainare related to abnormalities in emotion regulation in both human adolescents and nonhuman primates.Diffusion tensor imaging (DTI) will be used to characterize white matter microstructure of pathways (primarilythrough the uncinate fasciculus) between the amygdala and prefrontal cortex, which form the primary braincircuitry for emotion regulation. There are four aims of this project.
The first aim i s to related DTImeasurements in the uncinate fasciculus of monkeys to measures of amygdala reactivity and chronic stressexposure (with Project 1). We predict that monkeys with high amygdala reactivity and stress exposure willdemonstrate the most abnormal connections in this white matter region. The second and third aims are torelate DTI measures in the uncinate fasciculus of well-characterized human adolescent groups. (Projects 2and 3) to pediatric measures of cortisol (Project 2) and genetic versus experiential factors related tointernalizing disorders (Project 3). We predict that the uncinate fasciculus microstructure will be abnormal inadolescents with (a) high chronic levels of pediatric cortisol, and (b) risk of internalizing disorders.
The fourthaim i s to relate DTI measures in the uncinate fasciculus with fMRI measures of emotion regulation inadolescents (Project 4). We predict that the DTI properties of the uncinate fasciculus will be related to thefMRI signals in response to emotion regulation tasks

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH084051-01
Application #
7628826
Study Section
Special Emphasis Panel (ZMH1-ERB-A (01))
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-05-31
Support Year
1
Fiscal Year
2008
Total Cost
$253,490
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Amiri, Anahita; Coppola, Gianfilippo; Scuderi, Soraya et al. (2018) Transcriptome and epigenome landscape of human cortical development modeled in organoids. Science 362:
Wang, Daifeng; Liu, Shuang; Warrell, Jonathan et al. (2018) Comprehensive functional genomic resource and integrative model for the human brain. Science 362:
Curtis, David (2018) Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets. Psychiatr Genet 28:59-65
Gandal, Michael J; Haney, Jillian R; Parikshak, Neelroop N et al. (2018) Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science 359:693-697
Curtis, David (2018) Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia. Psychiatr Genet 28:85-89
Sarkisian, Katherine; Van Hulle, Carol; Lemery-Chalfant, Kathryn et al. (2017) Childhood inhibitory control and adolescent impulsivity and novelty seeking as differential predictors of relational and overt aggression. J Res Pers 67:144-150
Shackman, A J; Fox, A S; Oler, J A et al. (2017) Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology. Mol Psychiatry 22:724-732
Oler, Jonathan A; Tromp, Do P M; Fox, Andrew S et al. (2017) Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain Struct Funct 222:21-39
Adluru, Nagesh; Luo, Zhan; Van Hulle, Carol A et al. (2017) Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach. Sci Rep 7:8749
Kalin, Ned H (2017) Mechanisms underlying the early risk to develop anxiety and depression: A translational approach. Eur Neuropsychopharmacol 27:543-553

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