This Center seeks support for a major program of highly interdisciplinary research at the University of Wisconsin-Madison that uses an affective neuroscience perspective to further our understanding of the underlying neural and behavioral bases of risk for anxiety and mood disorders (internalizing disorders), with a specific focus on the adolescent period. Adolescence is a period of extraordinarily increased risk for these disorders and it is also a period during which dramatic maturational and experience-induced alterations in brain function and structure take place. Moreover, epidemiological evidence indicates a 2-3 fold increased risk in adulthood for these disorders if an individual had a diagnosis as an adolescent. Through a highly integrated and collaborative program of research in non-human primates and humans that involves five PI's all on the faculty at UW-Madison, this Center will produce novel new data over the next five years on the brain mechanisms and behavioral, endocrine and autonomic correlates of individual differences in emotion regulation and emotional reactivity. A major focus will be on early life predictors of adolescent brain circuits that underlie the regulation of emotion and abnormalities in these circuits in individuals vulnerable to internalizing disorders. The research strategies will also permit the examination of relations between early diatheses and later vulnerability in adolescence since longitudinal data are available in both human cohorts. In the non-human cohort, an explicit manipulation of early stress will be performed. The Center will also provide new strategies for parsing the heterogeneity of anxiety and mood disorders using profiles of brain function and structure. Each of the PIs involved in this Center have a long history of collaboration. There are many two, three and four way collaborations among the PIs. All have published with at least one other PI and many have published with many of the Center PIs. Each of the projects involves the collaborative involvement of all of the PIs. This overall program of work is critically dependent upon this entire team and the scope of the work and the multiple levels of analysis would only be possible within a Center. This team is highly experienced, has a demonstrated record of working well together, has been extraordinarily productive in the past, and promises to produce novel insights about the neural and behavioral bases of adolescent internalizing disorders that will directly inform diagnosis and treatment.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
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Special Emphasis Panel (ZMH1-ERB-A (01))
Program Officer
Avenevoli, Shelli A
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University of Wisconsin Madison
Other Domestic Higher Education
United States
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Brooker, Rebecca J; Canen, Mara J; Davidson, Richard J et al. (2017) Short- and long-term stability of alpha asymmetry in infants: Baseline and affective measures. Psychophysiology 54:1100-1109
Shackman, A J; Fox, A S; Oler, J A et al. (2017) Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology. Mol Psychiatry 22:724-732
Oler, Jonathan A; Tromp, Do P M; Fox, Andrew S et al. (2017) Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain Struct Funct 222:21-39
Sarkisian, Katherine; Van Hulle, Carol; Lemery-Chalfant, Kathryn et al. (2017) Childhood inhibitory control and adolescent impulsivity and novelty seeking as differential predictors of relational and overt aggression. J Res Pers 67:144-150
Adluru, Nagesh; Luo, Zhan; Van Hulle, Carol A et al. (2017) Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach. Sci Rep 7:8749
Kalin, Ned H (2017) Mechanisms underlying the early risk to develop anxiety and depression: A translational approach. Eur Neuropsychopharmacol 27:543-553
Chung, Moo K; Hanson, Jamie L; Adluru, Nagesh et al. (2017) Integrative Structural Brain Network Analysis in Diffusion Tensor Imaging. Brain Connect 7:331-346
Planalp, Elizabeth M; Van Hulle, Carol; Gagne, Jeffrey R et al. (2017) The Infant Version of the Laboratory Temperament Assessment Battery (Lab-TAB): Measurement Properties and Implications for Concepts of Temperament. Front Psychol 8:846
Hanson, Jamie L; van den Bos, Wouter; Roeber, Barbara J et al. (2017) Early adversity and learning: implications for typical and atypical behavioral development. J Child Psychol Psychiatry 58:770-778
Korponay, Cole; Dentico, Daniela; Kral, Tammi et al. (2017) Neurobiological correlates of impulsivity in healthy adults: Lower prefrontal gray matter volume and spontaneous eye-blink rate but greater resting-state functional connectivity in basal ganglia-thalamo-cortical circuitry. Neuroimage 157:288-296

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