In this project we will evaluate whether the microstructural properties of white matter connections in the brain are related to abnormalities in emotion regulation in both human adolescents and nonhuman primates. Diffusion tensor imaging (DTI) will be used to characterize white matter microstructure of pathways (primarily through the uncinate fasciculus) between the amygdala and prefrontal cortex, which form the primary brain circuitry for emotion regulation. There are four aims of this project.
The first aim i s to related DTI measurements in the uncinate fasciculus of monkeys to measures of amygdala reactivity and chronic stress exposure (with Project 1). We predict that monkeys with high amygdala reactivity and stress exposure will demonstrate the most abnormal connections in this white matter region. The second and third aims are to relate DTI measures in the uncinate fasciculus of well-characterized human adolescent groups. (Projects 2 and 3) to pediatric measures of cortisol (Project 2) and genetic versus experiential factors related to internalizing disorders (Project 3). We predict that the uncinate fasciculus microstructure will be abnormal in adolescents with (a) high chronic levels of pediatric cortisol, and (b) risk of internalizing disorders.
The fourth aim i s to relate DTI measures in the uncinate fasciculus with fMRI measures of emotion regulation in adolescents (Project 4). We predict that the DTI properties of the uncinate fasciculus will be related to the fMRI signals in response to emotion regulation tasks
|Brooker, Rebecca J; Canen, Mara J; Davidson, Richard J et al. (2017) Short- and long-term stability of alpha asymmetry in infants: Baseline and affective measures. Psychophysiology 54:1100-1109|
|Shackman, A J; Fox, A S; Oler, J A et al. (2017) Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology. Mol Psychiatry 22:724-732|
|Oler, Jonathan A; Tromp, Do P M; Fox, Andrew S et al. (2017) Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain Struct Funct 222:21-39|
|Sarkisian, Katherine; Van Hulle, Carol; Lemery-Chalfant, Kathryn et al. (2017) Childhood inhibitory control and adolescent impulsivity and novelty seeking as differential predictors of relational and overt aggression. J Res Pers 67:144-150|
|Adluru, Nagesh; Luo, Zhan; Van Hulle, Carol A et al. (2017) Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach. Sci Rep 7:8749|
|Kalin, Ned H (2017) Mechanisms underlying the early risk to develop anxiety and depression: A translational approach. Eur Neuropsychopharmacol 27:543-553|
|Chung, Moo K; Hanson, Jamie L; Adluru, Nagesh et al. (2017) Integrative Structural Brain Network Analysis in Diffusion Tensor Imaging. Brain Connect 7:331-346|
|Planalp, Elizabeth M; Van Hulle, Carol; Gagne, Jeffrey R et al. (2017) The Infant Version of the Laboratory Temperament Assessment Battery (Lab-TAB): Measurement Properties and Implications for Concepts of Temperament. Front Psychol 8:846|
|Hanson, Jamie L; van den Bos, Wouter; Roeber, Barbara J et al. (2017) Early adversity and learning: implications for typical and atypical behavioral development. J Child Psychol Psychiatry 58:770-778|
|Korponay, Cole; Dentico, Daniela; Kral, Tammi et al. (2017) Neurobiological correlates of impulsivity in healthy adults: Lower prefrontal gray matter volume and spontaneous eye-blink rate but greater resting-state functional connectivity in basal ganglia-thalamo-cortical circuitry. Neuroimage 157:288-296|
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